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NCT Number: NCT06849206

Pennington Generation Cohort

The Pennington Generation Cohort is an observational study comprised of Louisiana families. Families will be assessed at baseline for a variety of traits and behaviors, and then followed up over time to try to understand the role of lifestyle and the environment on the risk of developing obesity and other health outcomes.

Recruiting

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Key information

Sex eligibility

All sexes

Study type

Observational

Primary location

Pennington Biomedical Research Center

Baton Rouge, Louisiana, 70808, United States

Location status: Recruiting

Location contact

Peter T Katzmarzyk, PhD

CONTACT

[email protected]

225-763-2536

Peter T Katzmarzyk, PhD

PRINCIPAL_INVESTIGATOR

About this study

Pennington Biomedical's Greaux Healthy initiative partners with communities to grow healthier generations by expanding the access and reach of Pennington Biomedical's evidence-based practices for the prevention and treatment of childhood obesity. As part of Greaux Healthy, the Pennington Generation Cohort will help evaluate the impact of the program. A sample of up to 1,500 children and adolescents and their families will be recruited from throughout Louisiana. An initial physical exam will establish a baseline for each family with respect to lifestyle behaviors, genetics, and body size/composition. This longitudinal cohort will also assess the association between participation in several childhood obesity prevention and treatment programs and subsequent obesity and related health outcomes. Members of the longitudinal cohort will be followed in the future through clinical visits, questionnaires, and through optional linkages to electronic medical records and administrative databases such as the National Death Index, Social Security Death Master File, and health registry data.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Children, adolescents, and young adults (birth through age 24 years) and their nuclear family members* and adults age 25+ who are expectant parents or are trying to conceive
  • Self-reported resident of Louisiana
  • Ability to understand instructions and complete all study procedures
  • Able to provide informed consent (adults aged over 18 years)
  • Able to provide assent (children 9 to 17 years)
  • Able to communicate (oral and written) in English

Exclusion criteria

  • Discretion of the Medical Monitor or Principal Investigator

Treatment and study plan

Primary outcomes

  1. Obesity

    Time frame: From enrollment up to 20 years of follow-up.

    The development of obesity, defined using BMI z-scores during childhood, and BMI during adulthood.

Secondary outcomes

  1. Weight change

    Time frame: From enrollment up to 20 years of follow-up.

    Change in body weight.

  2. Mortality

    Time frame: From enrollment up to 20 years of follow-up..

    Data from the Pennington Generation Prospective Cohort will be prospectively linked to the National Death Index for the ascertainment of mortality.

  3. Cancer incidence

    Time frame: From enrollment up to 20 years of follow-up..

    Data from the Pennington Generation Prospective Cohort will be prospectively linked to the Louisiana Tumor Registry for the ascertainment of incident cancer.

Study contacts

Contact information is provided by the study sponsor or research team.

Kara Denstel, PhD

CONTACT

[email protected]

763-2614

Peter T Katzmarzyk, PhD

CONTACT

[email protected]

225-763-2536

Sponsors and collaborators

Lead sponsor

Pennington Biomedical Research Center

Other

Registry information

Important dates

Study start
2025
Primary completion
2045
Study completion
2045
First posted
Feb 27, 2025
Registry last updated
Mar 17, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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