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NCT Number: NCT01255670

Penicillin and Metronidazole in Treatment of Peritonsillar Abscess

Treatment of peritonsillar abscess varies. To study whether broad spectrum antibiotics are required in addition to abscess drainage, a prospective, double blind, placebo-controlled, randomized study on 200 adult patients with peritonsillar abscess is performed. 100 patients are given penicillin and metronidazole and 100 patients get penicillin and placebo. Recovery and recurrence are analyzed.

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Key information

Conditions

Peritonsillar Abscess Abscess Disease Attributes Infections Otorhinolaryngologic Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Pharyngeal Diseases Pharyngitis Recurrence Respiratory Tract Diseases Respiratory Tract Infections Stomatognathic Diseases Suppuration Tonsillitis

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Helsinki University Central Hospital

Helsinki, 00029, Finland

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • referring doctor suspects peritonsillar abscess
  • patient is voluntary
  • patient has daily access to his/her e-mail
  • patient speaks and understands Finnish of Swedish
  • female patients have adequate birth-control method
  • patient has peritonsillar abscess

Exclusion criteria

  • allergy to penicillin
  • allergy to metronidazole
  • use of metronidazole in preceding one month
  • pregnancy
  • breast-feeding
  • renal insufficiency
  • liver insufficiency
  • alcoholism (drunk at least once a week)
  • participant in another clinical trial at the moment
  • treatment of peritonsillar abscess requires in-patient care
  • tonsillectomy during the next 30 days
  • army recruit

Treatment and study plan

penicillin and metronidazole in peritonsillar abscess

Drug

Peroral Penicillin: 1000 000 IU 3 times a day for 10 days Peroral metronidazole: 500 mg 3 times a day for 7 days

Other names: Medicillin, Flagyl, Tricozol

Primary outcomes

  1. Number of Participants With Recurrence of Peritonsillar Abscess

    Time frame: 56 days

    Number of participants with recurrence of peritonsillar abscess having metronidazole in addition to penicillin or penicillin and placebo.

Secondary outcomes

  1. Number of Participants Recovering From Peritonsillar Abscess

    Time frame: 28 days

    Number of participants recovering from peritonsillar abscess having metronidazole in addition to penicillin or penicillin and placebo.

Sponsors and collaborators

Lead sponsor

Helsinki University Central Hospital

Other

Registry information

Official study title

Penicillin and Metronidazole in Treatment of Peritonsillar Abscess - Prospective, Double-blind, Randomized, Placebo-controlled Study

Important dates

Study start
2010
Primary completion
2011
Study completion
2011
First posted
Dec 7, 2010
Registry last updated
May 11, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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