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NCT Number: NCT07023094

PENG With LFCB vs. ESP Blocks for Pediatric Hip Surgery

This randomized controlled trial (RCT) compares the analgesic effectiveness of two regional anesthesia techniques-Pericapsular Nerve Group (PENG) block combined with Lateral Femoral Cutaneous Nerve Block (LFCB) versus Lumbar and Sacral Erector Spinae Plane Blocks (L-ESPB and S-ESPB)-in pediatric patients undergoing hip surgery.

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Key information

Age range

2 year–16 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Poznan University of Medical Sciences

Poznan, Poland

Location status: Recruiting

Location contact

Malgorzata Reysner, MD. Ph.D.

CONTACT

[email protected]

+608762068

About this study

Orthopedic hip procedures in pediatric patients, including osteotomies, arthroscopic interventions, and reconstructive surgeries, often result in significant postoperative pain. Effective analgesia is critical for reducing surgical stress, accelerating rehabilitation, and minimizing opioid use and associated side effects. Regional anesthesia techniques have gained attention for their opioid-sparing effects and enhanced recovery profiles.

This randomized controlled trial aims to compare the analgesic effectiveness of two regional anesthetic approaches:

  • The pericapsular nerve group (PENG) block is combined with the lateral fetal cutaneous nerve block (LFCB), targeting hip joint innervation directly and providing comprehensive sensory coverage.

Lumbar and sacral erector spinae plane blocks (L-ESPB and S-ESPB) employ fascial plane techniques to deliver analgesia by diffusing local anesthetic around nerves innervating the hip region.

This trial aims to establish the optimal regional anesthesia technique and determine the clinical benefits of using dexamethasone and dexmedetomidine as adjuvants. The results will guide clinicians toward evidence-based analgesic protocols in pediatric orthopedic hip surgery, potentially reducing opioid-related complications and improving patient recovery outcomes.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Pediatric patients aged between 2 and 16 years.
  • Scheduled for elective orthopedic hip surgery, including: Osteotomies and Hip reconstruction surgeries
  • ASA (American Society of Anesthesiologists) physical status classification: I-III.
  • Written informed consent obtained from the patient's legal guardian(s).

Exclusion criteria

  • Known allergy or hypersensitivity to any of the study medications
  • Presence of infection or inflammation at the intended injection site(s) of regional anesthesia.
  • Coagulopathy or bleeding disorders (including patients on anticoagulant therapy) that contraindicate nerve blocks.
  • Neurological disorders or peripheral neuropathies that could influence sensory or motor assessment of the lower limbs.
  • Cognitive impairment or behavioral disorders significantly affecting pain assessment accuracy or cooperation.
  • History of chronic opioid use or known substance abuse.
  • Severe systemic disease or condition compromising patient safety or interfering with study protocol adherence.

Treatment and study plan

Ropivacaine 0.2% for PENG Block

Drug

U-S guided PENG (0.4 mL/kg) with 0.2% ropivacaine

Ropivacaine 0.2% for LFCB

Drug

LFCB (0.1 mL/kg) with 0.2% ropivacaine

Ropivacaine 0.2% for L-ESPB

Drug

Lumbar ESPB (0.25ml/kg) with 0.2% ropivacaine

Ropivacaine 0.2% for S-ESPB

Drug

Sacral ESPB (0.25ml/kg) with 0.2% ropivacaine

Primary outcomes

  1. Total Opioid Consumption

    Time frame: 48 hours after surgery

    Total opiate consumption after surgery

Secondary outcomes

  1. Time to first rescue opioid analgesia

    Time frame: 48 hours after surgery

    Time after surgery when the patient needs opiate for the first time

  2. Numerical Rating Scale [range 0:10]

    Time frame: 4 hours after surgery

    Postoperative pain assessment will be performed using the NRS score (0 = no pain, 10 = the most severe pain felt)

  3. Numerical Rating Scale [range 0:10]

    Time frame: 8 hours after surgery

    Postoperative pain assessment will be performed using the NRS score (0 = no pain, 10 = the most severe pain felt)

  4. Numerical Rating Scale [range 0:10]

    Time frame: 12 hours after surgery

    Postoperative pain assessment will be performed using the NRS score (0 = no pain, 10 = the most severe pain felt)

  5. Numerical Rating Scale [range 0:10]

    Time frame: 24 hours after surgery

    Postoperative pain assessment will be performed using the NRS score (0 = no pain, 10 = the most severe pain felt)

  6. Numerical Rating Scale [range 0:10]

    Time frame: 48 hours after surgery

    Postoperative pain assessment will be performed using the NRS score (0 = no pain, 10 = the most severe pain felt)

  7. NLR

    Time frame: 12 hours after surgery

    neutrophile to lymphocyte ratio

  8. NLR

    Time frame: 24 hours after surgery

    neutrophile to lymphocyte ratio

  9. NLR

    Time frame: 48 hours after surgery

    neutrophile to lymphocyte ratio

  10. PLR

    Time frame: 12 hours after surgery

    platelet to lymphocyte ratio

  11. PLR

    Time frame: 24 hours after surgery

    platelet to lymphocyte ratio

  12. PLR

    Time frame: 48 hours after surgery

    platelet to lymphocyte ratio

Study contacts

Contact information is provided by the study sponsor or research team.

Malgorzata Reysner

CONTACT

[email protected]

+48 61 873 83 03

Sponsors and collaborators

Lead sponsor

Poznan University of Medical Sciences

Other

Registry information

Official study title

Comparison of Analgesic Efficacy of Pericapsular Nerve Group (PENG) Block With Lateral Femoral Cutaneous Nerve Block (LFCB) Versus Lumbar and Sacral Erector Spinae Plane Blocks (L-ESPB and S-ESPB) in Pediatric Hip Surgery: A Randomized Controlled Trial

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jun 15, 2025
Registry last updated
Jul 11, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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