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OpenTrials
Completed

NCT Number: NCT02513758

Penetration and Compartimentation of HIV

Genital mucosa is the main way of HIV penetration. Many cells can be involved (epithelial cells, Langerhans cells) and antibodies may also play a critical role. The investigators' study aims to precise the role of each type of cells, the interaction cell-cell and cell-antibodies.

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Key information

Conditions

HIV

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

LUCHT

Saint-Etienne, 42055, France

About this study

At inclusion, men will have a two blood sampling tubes of 10 ml each, a saliva sample and a sample of sperm and women will have a two blood sampling tubes of 10 ml each, a saliva sample and a sampling cervicovaginal secretions

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults (> 18 year-old) HIV positive,
  • HIV-CV> 1000 cp/ml,

Exclusion criteria

  • children

Treatment and study plan

Sample

Other

Men will have blood sampling tubes of 10 ml each, a saliva sample and a sample of sperm Women will have a two blood sampling tubes of 10 ml each, a saliva sample and a sampling cervicovaginal secretions

Primary outcomes

  1. Viral tropism of HIV

    Time frame: Inclusion

    number of HIV virus in sperm or cervical secretions.

Secondary outcomes

  1. Genetic polymorphism for HIV strains

    Time frame: Inclusion

    With a sequencing method, it is possible to classify the different strains in groups, according to their polymorphism.

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Saint Etienne

Other

Registry information

Official study title

Penetration and Compartimentation of HIV in Genital Mucosa

Important dates

Study start
2002
Primary completion
2014
Study completion
2014
First posted
Aug 3, 2015
Registry last updated
Mar 23, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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