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OpenTrials
Completed

NCT Number: NCT06803810

Peer to Peer (P2P): Mental Health Interventions With Persons With Substance Use Disorders

This study provides substance use and mental health peer support services to address behavioral health disparities in rural areas. Specifically, the project aims to address persistent mental health symptoms, such as anxiety and depression, that become barriers to care for patients working towards long-term recovery from co-occurring mental health and substance use disorders. Participants will be assessed and evaluated for opioid use disorder (OUD), social determinants of health (SDoH), and infectious diseases by a nurse practitioner and a social worker. A certified peer support specialist (CPSS) will provide additional support, connecting patients to sustainable mental health resources and implementing a modified version of the Friendship Bench intervention, which involves six weekly 45-minute problem-solving therapy sessions with the option to participate in six or more peer support sessions. The CPSS will follow the patient for up to 12 weeks.

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Key information

Conditions

Standard of Care P2P Intervention

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Prisma Health

Greenville, South Carolina, 29605, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosis of OUD via Diagnostic Statistical Manual (DSM)-V Text Revision (TR)
  • Receiving MOUD through the Mobile Recovery Program for at least 3 months
  • Age 18 or older
  • Moderate to Severe Depression with or without co-occurring anxiety as determined by PHQ-9 conducted during the most recent MRP clinical visit

Exclusion criteria

  • Severe cognitive, medical, or psychiatric disability that could impair ability to perform study-related activities as determined by the MRP clinician or principal investigator.
  • Unable to read/speak English
  • Unable to read and comprehend the consent materials and other study materials
  • Current suicidal ideation based on the Patient Health Questionnaire-9

Treatment and study plan

P2P Intervention

Behavioral

This group will complete the same study visits as the standard care group with an additional week 3 visit and 6 CPSS-led therapy intervention sessions. These CPSS led sessions will be completed by the end of the 12week study period. At each study visit you will complete questionnaires.

Primary outcomes

  1. Reduction in depressive symptoms

    Time frame: 12 weeks

    Reduce depression symptoms as measured by the PHQ-9

Sponsors and collaborators

Lead sponsor

Prisma Health-Upstate

Other

Collaborators

  • South Carolina Center for Rural and Primary Healthcare

Registry information

Acronym: P2P

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Jan 31, 2025
Registry last updated
Feb 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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