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NCT Number: NCT07219394

Peer-Delivered Behavioral Activation in a CCBHC

Low-income individuals have limited access to evidence-based interventions for mental health. Peer recovery specialists, individuals in recovery from mental health and/or substance use problems, have the potential to increase access to evidence-based interventions for individuals from low-resource communities, particularly when trained and supervised in models that are acceptable and feasible in these communities. This study will examine the effectiveness and implementation potential of a peer-delivered evidence-based intervention (Behavioral Activation) among individuals receiving services from a community-based treatment setting providing integrated physical and behavioral healthcare.

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Key information

Conditions

Major Depressive Disorder Chemically-Induced Disorders Depressive Disorder Depressive Disorder, Major Mental Disorders Mood Disorders Substance Use Disorders Substance-Related Disorders

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Detroit Recovery Project

Detroit, Michigan, 48208, United States

Location status: Recruiting

Location contact

Andre Johnson, PhD

CONTACT

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18 years old or older
  • Report clinically-significant symptoms of depression, as indexed by a score of 8+ on the PHQ-9.

Exclusion criteria

  • Active, under treated psychotic symptoms or mania that would interfere with participation in study procedures
  • Inability to provide informed consent and/or complete procedures in English

Treatment and study plan

Peer Activate

Behavioral

Peer Activate is an adapted behavioral activation (BA) intervention, developed for delivery by peer recovery specialists to reduce rates of depressive symptoms and substance use. BA focuses on increasing positive reinforcement through engaging in adaptive, valued behaviors. BA has been found to be effective in improving substance use outcomes and decreasing depressive symptoms among low-income individuals with SUD. Peer Activate includes 6 weekly sessions with up to 6 additional booster sessions.

Peer-delivered non-specific services

Behavioral

Peers will deliver non-specific peer services, including linkage to care, general support, and facilitated referrals to external providers as needed.

Primary outcomes

  1. Change in Hamilton Depression Rating Scale

    Time frame: Baseline, post-intervention (approximately 3 months after baseline), 6- and 12-month follow-up

    The Hamilton Depression Rating Scale (HAM-D) is a structured interview regarding patients' symptoms of depression and functional impairment. The HAM-D will be administered by research assistants under the supervision of the MPI (Felton) at baseline, post-intervention, 6- and 12-month follow-up. The measure is widely used in depression and substance use treatment studies and has excellent psychometric properties. Nine items are scored 0-4 and 8 items are scored 0-2, with higher scores reflecting greater levels of depressive symptoms. A total score will be calculated by summing each other items. Summed total scores can range from 0-52, with higher values reflecting greater depression.

Secondary outcomes

  1. Change in Patient Health Questionnaire-9

    Time frame: Baseline, post-intervention (approximately 3 months after baseline), 6- and 12-month follow-up

    The Patient Health Questionnaire-9 (PHQ-9) is a self-report measure of depressive symptoms. Participants will complete the PHQ-9 at baseline, post-intervention, 6- and 12-month follow-up. The measure is valid and reliable in low-resource community settings. The measure includes nine items which are scored from 0-3, with 3 reflecting more severe levels of each depressive symptom. A total score is created by summing items with a possible range from 0-27 (with higher scores reflecting greater depressive symptoms).

  2. Change in Short Inventory of Problems

    Time frame: Baseline, post-intervention (approximately 3 months after baseline), 6- and 12-month follow-up

    The Short Inventory of Problems is a self-report measure of problems related to substance use. Participants will complete the SIP at baseline, post-intervention, 6- and 12-month follow-up. The measure is valid and reliable and has been used by the investigator team in numerous studies among low-income populations. The measure includes 17 items, each ranked from 0-3 with higher scores reflecting greater problems related to alcohol and substance use. A total score is created by summing each item and can range from 0-51 with higher values reflecting more substance-related problems.

Study contacts

Contact information is provided by the study sponsor or research team.

Julia Felton, PhD

CONTACT

[email protected]

7049957832

Sponsors and collaborators

Lead sponsor

Wayne State University

Other

Collaborators

  • Detroit Recovery Project INC
  • University of Maryland, College Park

Registry information

Official study title

Hybrid Effectiveness-Implementation Trial to Evaluate a Scalable, Peer-Delivered Intervention for Depression Among People With Substance Use Disorder in a Certified Community Behavioral Health Clinic

Important dates

Study start
2026
Primary completion
2029
Study completion
2029
First posted
Oct 21, 2025
Registry last updated
Apr 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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