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NCT Number: NCT06594601

PEEP Titration and Lung Recruitment Potential Assessed by 3D EIT

In a population of ARDS patients, we explore the influence of different PEEP levels on regional ventilation distribution, ventilation homogeneity, and the center of ventilation, optimal PEEP and lung recruitment potential as well as the extent of lung collapse and overdistension as detected by 3D-EIT.

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Key information

Conditions

ARDS Respiration Disorders Respiratory Failure Respiratory Insufficiency Respiratory Tract Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences,

Beijing, Beijing Municipality, 100730, China

Location status: Recruiting

Location contact

Huaiwu He, MM

CONTACT

Long Yun, MD

CONTACT

[email protected]

Long Yun, MD

CONTACT

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients on mechanical ventilation.
  • Diagnosis of ARDS was based on the Berlin definition
  • lung recruitment potential assessment and PEEP titration was proper for the ARDS patients determined by the attending doctor

Exclusion criteria

  • Under 18 years of age.
  • Pregnant women;
  • Ribcage malformation
  • Any contraindication to the use of EIT (e.g. automatic implantable cardioverter defibrillator, and implantable pumps).
  • Hemodynamic instability, unable to tolerate high PEEP;
  • High-risk individuals with pneumothorax, mediastinal emphysema, etc.

Treatment and study plan

lung recruitment potential assessed by 3D EIT

Procedure

Patients were ventilated based on the ARDS-Net suggestions. The patients were kept at supine position. The lung recruitment potential assessed by 3D EIT was as follows:

  • All patients were under pressure control mode (driving pressure 12-15 cmH2O with a tidal volume of 6-8 ml/kg predicted body weight, respiration rate12-15 bpm).
  • PEEP was switched to a zero end-expiratory pressure (ZEEP) for 10 min, and FiO2 was titrated to obtain peripheral oxygen saturation (SpO2 ) > 90%.
  • PEEP was stepwise increase from 0 to 15 cmH2O PEEP in steps of 5cm H2O every 3min.And 3D EIT was used to assess lung recruitment potential.

PEEP titration by 3D eit

Procedure

Patients were ventilated based on the ARDS-Net suggestions. The patients were kept at supine position. The PEEP titriatino by 3D EIT fwas as follows:

  • All patients were under pressure control mode (driving pressure 12-15 cmH2O with a tidal volume of 6-8 ml/kg predicted body weight, respiration rate12-15 bpm).
  • RM: PEEP was switched to a 21cmH2O for 2min, and FiO2 was titrated to obtain peripheral oxygen saturation (SpO2 ) ≥90%.
  • PEEP was stepwise decrease from 21 to 0 cmH2O PEEP in steps of 3cm H2O every 2min.
  • 3D EIT was used to monitor regional ventilation distribution during PEEP titration.

Primary outcomes

  1. OD/CL and optimal PEEP monitored by EIT

    Time frame: 5-10min

    Monitoring the lung collapse and overdistension region by EIT at different PEEP levels. Measure the optimal PEEP level based on collapse and overdistension rate.

Secondary outcomes

  1. ventilation distribution monitored by EIT

    Time frame: 5-10min

    Monitoring the lung ventilation distribution by EIT at different PEEP levels

  2. GI monitored by EIT

    Time frame: 5-10min

    Global Inhomogeneity (GI) Index monitored by EIT at different PEEP levels

  3. CoV monitored by EIT

    Time frame: 5-10min

    Center of ventilation (COV) monitored by EIT at different PEEP levels

  4. V/Q monitored by EIT

    Time frame: 5-10min

    Ventilation and perfusion monitored by EIT at different PEEP levels. To evaluate the V/Q match, deadspace and shunt lung region.

Study contacts

Contact information is provided by the study sponsor or research team.

Huaiwu He

CONTACT

[email protected]

15201518815

Sponsors and collaborators

Lead sponsor

Peking Union Medical College Hospital

Other

Registry information

Official study title

PEEP Titration and Lung Recruitment Potential Assessment by 3D EIT in ARDS Patients

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Sep 19, 2024
Registry last updated
Sep 19, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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