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OpenTrials
Completed

NCT Number: NCT05115526

PEEP Setting in COVID19-related ARDS

The best way to titrate positive end-expiratory pressure (PEEP) in patients suffering from acute respiratory distress syndrome is still matter of debate. Electrical impedance tomography (EIT) in a non-invasive technique that could guide PEEP setting based on an optimized ventilation homogeneity.

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Key information

Conditions

ARDS Due to Severe Acute Respiratory Syndrome Coronavirus 2

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Service de Réanimation Médicale, Hôpital Central

Nancy, France

About this study

COVID-19 related ARDS patients admitted to the ICU in March 2021 requiring mechanical ventilation were enrolled. Patients were monitored by an esophageal catheter and a 32-electrode EIT device. Within 48 hours after the start of mechanical ventilation, different levels of PEEP were applied based upon PEEP/ Fraction of inspired oxygen tables, positive end-expiratory transpulmonary (PL)/ FiO2 table, and EIT. Respiratory mechanics variables were recorded.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • COVID19-related ARDS under invasive mechanical ventilation

Exclusion criteria

  • none

Treatment and study plan

PEEP setting

Other

PEEP setting according to various methods

Primary outcomes

  1. Value of PEEP

    Time frame: a single determination, within 24-48 hours after mechanical ventilation initiation

    different PEEP values obtained through using different methods

Secondary outcomes

  1. Respiratory mechanics

    Time frame: a single determination, within 24-48 hours after mechanical ventilation initiation

    Respiratory mechanics (plateau pressure, driving pressure, compliance, mechanical power) following different PEEP settings

Sponsors and collaborators

Lead sponsor

Central Hospital, Nancy, France

Other

Registry information

Official study title

Positive End-expiratory Pressure Setting in COVID-19 Related ARDS : Comparison Between Electrical Impedance Tomography, PEEP/ Fraction of Inspired Oxygen Tables, and Transpulmonary Pressure.

Important dates

Study start
2021
Primary completion
2021
Study completion
2021
First posted
Nov 10, 2021
Registry last updated
Nov 10, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.