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NCT Number: NCT03420391

PBMT on Muscular Performance and Recovery in Different Time-points

Recent studies with photobiomodulation therapy (PBMT) have shown positive results delaying skeletal muscle fatigue and improving the status of biochemical markers related to skeletal muscle damage when these therapies were applied before exercise. The aim of this project is to verify the effects of PBMT in improvement of skeletal muscle performance and skeletal muscle recovery in healthy male subjects. This project aim also to validate the concept that simultaneous use of three wavelengths and light sources lead to optimized action independently of time-window between irradiation and the exercise.

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Key information

Conditions

Phototherapy

Age range

18 year–35 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Universidade Nove de Julho

São Paulo, 01504-001, Brazil

About this study

This is a randomized, triple-blinded, placebo-controlled trial. Sixty healthy untrained male subjects will be randomly allocated to six experimental groups: Placebo, Control, PBMT 5 mins, PBMT 3h, PBMT 6h and PBMT 24 hours. PBMT will be applied precisely two minutes after baseline MVC test. Then, after five minutes, 3, 6 hours or 1 day (24 hours) of PBMT the eccentric exercise protocol will be performed. We will analyze maximum voluntary contraction (MVC), creatine kinase (CK) activity and delayed onset muscle soreness (DOMS). Assessments will be performed at baseline, immediately after (1 minute), 1 hour, 24 and 48 hours after the eccentric exercise protocol.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy
  • not athletes or who engage in physical activity at most once a week
  • Individuals should not present a history of musculoskeletal injury in the hip and knee regions in the two months prior to the studies
  • they should not be using pharmacological agents and / or nutritional supplements
  • They must attend 100% of the data collections.

Exclusion criteria

  • Individuals who do not meet the criteria mentioned above or who present musculoskeletal damage during collection were excluded from the study.

Treatment and study plan

Photobiomodulation therapy (PBMT)

Device

Phototherapy device - Multi Radiance Medical® (Solon, OH, EUA)

Primary outcomes

  1. Torque peak / maximum voluntary contraction - MVC

    Time frame: 1 minute, 1 hour, 24 and 48 hours after the end of exercise protocol.

    Assessment was performed in the isokinetic dynamometer (System 4, Biodex®, USA)

Secondary outcomes

  1. Delayed onset muscle soreness (DOMS)

    Time frame: 1 minute, 1 hour, 24 and 48 hours after the end of exercise protocol.

    Assessment was performed through visual analogue scale (VAS). A visual analogue scale (VAS) of 100 mm was used as a self-rating of volunteers DOMS intensity, with assistance of a blinded researcher, where "0" corresponds to no pain and 100mm corresponds to the worst pain possible.

  2. Biochemical marker of muscle damage

    Time frame: 1 minute, 1 hour, 24 and 48 hours after the end of exercise protocol.

    Analysis of Creatine Kinase (CK) levels

Sponsors and collaborators

Lead sponsor

University of Nove de Julho

Other

Collaborators

  • Fundação de Amparo à Pesquisa do Estado de São Paulo
  • University of Bergen

Registry information

Official study title

Effects of Photobiomodulation Therapy (PBMT) on Muscular Performance and Recovery in Different Time-points

Important dates

Study start
2019
Primary completion
2019
Study completion
2019
First posted
Feb 5, 2018
Registry last updated
Apr 28, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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