Pattern of Acute on Chronic Liver Failure in Patient With HCV Related Chronic Liver Disease

The concept of acute-on-chronic liver failure (ACLF) was introduced by Jalan and Williams in 2002 to describe the acute deterioration in liver function over 2 to 4 weeks in a patient with well-compensated cirrhosis associated with a precipitating event (hepatotoxic: superimposed hepatitis viral infection, drug-induced liver injury, hepatotoxins, or excessive alcohol consumption; extra hepatic: variceal bleeding or sepsis), leading to severe deterioration in clinical status with jaundice and hepatic encephalopathy and/or HRS. Following this concept, several proposals for the diagnostic criteria of ACLF have been suggested.

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Key information

Conditions

Acute-On-Chronic Liver Failure Digestive System Diseases Hepatic Insufficiency Liver Diseases Liver Failure Liver Failure, Acute

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Al-Rajhi Liver Hospital, Assiut University, Asyut, Egypt

About this study

There may be regional differences in etiology, pathogenesis, and natural course of ACLF, which may in turn influence the overall outcome of this syndrome. So, proper diagnosis of ACLF and its precipitating factors in our locality enable us for proper management of these cases and dealing with these precipitating factors to be avoided later on in patients with liver cirrhosis

Aim of the work:

To identify the pattern of acute on chronic liver cell failure (ACLF) within 28 days including prevalence, percipitating factors, and outcome.

Patients and methods

Type of the study: Prospective hospital based study

Site of the study: Tropical Medicine and Gastroenterology Department, Al-Rajhi University Hospital, Assiut University Hospitals, Assiut, Egypt. Written consent will be obtained from all the participants or their relatives before enrollment.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adult Patients with HCV related CLD based on clinical, biochemical and imaging evidence., with or without prior decompensation.
Patients diagnosed to have ACLIF at any grade (1-3)

Exclusion criteria

Acute liver failure without evidence of chronic liver disease.
Other etiology of chronic liver disease
Patients diagnosed with no ACLIF No ACLF
This category includes patients who either:

Do not have any organ failure
Have a single organ failure that does not involve the kidney with a serum creatinine level of <1.5 mg per dl and no hepatic encephalopathy
Have a single brain failure with a serum creatinine level of <1.5 mg per dl
Patients refuse to participate.

Treatment and study plan

Primary outcomes

pattern of acute on chronic liver cell failure

Time frame: march 2018 to march 2019

evaluation of cases with acute on chronic liver cell failure as number of cases diagnosed with ACLF in this period , the precipitating factor of the condition , the fate of the patient (improving or deterioration or death ) in the 28 days following diagnosis .

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Important dates

Study start: 2018
Primary completion: 2019
Study completion: 2019
First posted: Mar 7, 2018
Registry last updated: Jan 23, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed