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OpenTrials
Completed

NCT Number: NCT04976439

Patogenic Mutation in 5 Genes

This is a pathogenic mutation profile of colorectal patients specifically in 5 genes, i.e. APC, TP53, PIK3CA, KRAS, and MLH1. Single nucleotide variants identified were synchronized with patients' characteristics.

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Key information

Conditions

Colorectal Cancer APC Gene Mutation Colonic Diseases Colorectal Neoplasms Digestive System Diseases Digestive System Neoplasms Gastrointestinal Diseases Gastrointestinal Neoplasms Intestinal Diseases Intestinal Neoplasms KRAS Mutation-Related Tumors MLH1 Gene Mutation Neoplasms Neoplasms by Site PIK3CA Gene Mutation Rectal Diseases TP53 Gene Mutation

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Vania Myralda Giamour Marbun

Jakarta, ALL, 12740, Indonesia

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • FFPE samples fullfilling purity criterion and pass quality control

Exclusion criteria

  • none

Treatment and study plan

co-occuring mutation

Other

APC, TP53, PIK3CA, KRAS APC, TP53, PIK3CA, MLH1 APC, TP53, PIK3CA, KRAS, and MLH1 APC, TP53, PIK3CA

Primary outcomes

  1. Description of clinical characteristics

    Time frame: January 2017 - June 2021

    Age, gender

  2. Description of tumor nature

    Time frame: January 2017 - June 2021

    grade, stage, lymphovascular invasion, tumor location

  3. Description of survival

    Time frame: January 2017 - June 2021

    Median of life expectancy

Sponsors and collaborators

Lead sponsor

Dr Cipto Mangunkusumo General Hospital

Other

Registry information

Official study title

Genomic Landscape of APC, KRAS, TP53, PIK3CA, and MLH1 in Colorectal

Important dates

Study start
2021
Primary completion
2021
Study completion
2021
First posted
Jul 26, 2021
Registry last updated
Jul 26, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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