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OpenTrials
Completed

NCT Number: NCT06832891

Patient Preferences in Empathetic Communication by AI vs Human Authorship

This study aims to evaluate whether patients have different preference patterns for empathetic communication through AI vs human-being when knowledge of authorship is known vs blinded.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States

About this study

Hypothesis:

Patients will express increased preference for human-generated empathetic communication vs AI-generated empathetic communication when they are made aware of authorship vs when blinded to it.

Aims, purpose, or objectives:

Evaluate if patients have different preference patterns for empathetic communication through AI vs human-being when knowledge of authorship is known vs blinded

Background:

Artificial intelligence (AI) is rapidly gaining a foothold in the healthcare industry. AI's role in healthcare can largely be divided into two sets of tasks: Those which involve direct interaction with patients and those which do not. Many tasks which do not directly interact with patients, such as monitoring and resupplying medications, delivering goods across a hospital, and analyzing practice trends and outcomes are highly likely to benefit from the efficiency, cost-savings, and consistency AI can provide. Tasks involving direct patient interaction are considerably more controversial. Understanding of how patients will respond to AI communication remains quite limited which is concerning considering the rapid expansion of AI into the healthcare space. A logical first step to investigate is to see if patients react to AI communication when they are blinded to it vs when authorship is known. This concept has previously been tested in other industries such as business and the law, but patient communication preference in healthcare has been little studied, especially in palliative care. It is the aim of this study to investigate this.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients over the age of 18 being seen in palliative care clinic who have already established care and with diagnosis of any malignancy

Exclusion criteria

  • Inability to consent defined as: Acute mental status changes (delirium/encephalopathy), acute substance intoxication, intellectual disability, dementia, patient with active legal guardian
  • Major psychiatric disorders including, but not limited to, bipolar disorder, psychotic disorders, active substance use disorder, and patients with active suicidal or homicidal thoughts.
  • NOTE: Patients with history of normal grieving reactions, major unipolar depressive disorder, posttraumatic stress disorder or generalized anxiety disorder would NOT be excluded.
  • Inability to read in English

Treatment and study plan

Survey

Other

Patients complete survey

Primary outcomes

  1. Preference patterns for empathetic communication

    Time frame: Baseline

    Assessed by a brief survey: patients will be show two brief empathetic statements related to their serious illness diagnosis (Cancer), one generated by Artificial Intelligence (AI) and one generated by a human physician in palliative care who were both given the same writing instructions and generated their responses independently. Half of the surveys will label which statement is generated by human or AI unblinded group) and the other half will be blinded to statement authorship. Preference will be compared between the blinded and unblinded groups.

Sponsors and collaborators

Lead sponsor

Mayo Clinic

Other

Registry information

Official study title

A Survey of Patient Preferences on Empathetic Communication in Outpatient Palliative Care

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Feb 18, 2025
Registry last updated
Aug 14, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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