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NCT Number: NCT02572778

Patient-derived Xenograft Models of Tumor From Patients With Head and Neck Cancer

The investigators want to have a collection of fresh primary or recurrent tumor tissue for establishment of patients-derived xenografts in order to:

generate a biobank of in vivo patient xenografts representing the different subgroups of tumors for head and neck cancer

* perform genetic and transcriptional profiling of the primary, metastatic tumors and xenograft tumors * evaluate the efficacy of new targeted agents, whether or not in combination with standard treatment options * evaluate biomarkers of drug sensitivity * study primary and secondary (acquired) resistance in these models

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Key information

Conditions

Squamous Cell Carcinoma of the Head and Neck Carcinoma Carcinoma, Squamous Cell Head and Neck Neoplasms Neoplasms Neoplasms by Histologic Type Neoplasms by Site Neoplasms, Glandular and Epithelial Squamous Cell Carcinoma of Head and Neck

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Cliniques universitaires Saint-Luc

Brussels, 1200, Belgium

Location status: Recruiting

Location contact

Aline Gillain, MedSciences

CONTACT

[email protected]

Jean-Pascal Machiels, MD, PhD

CONTACT

[email protected]

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • In the first phase, all patients with primary or recurrent/ metastatic disease of head and neck cancer can be included pre-operatively or before a tumor biopsy after obtaining informed consent
  • Data on stage, grade, histology, adjuvant treatment, responses, relapse should be available
  • Follow-up data should be available
  • Patients with recurrent disease are allowed
  • Written informed consent

Treatment and study plan

Local biopsy in the tumor

Procedure

A tumor biopsy of 0.5 cm2 or more will be collected from every patient during surgery or endoscopy after informed consent and if there is enough material after review by the pathologist.

Primary outcomes

  1. Identification of the biomarkers of new cancer therapies for head and neck cancer on the patient-derived xenografts with immunohistochemistry (KI67) on FFPE (fixation followed by paraffin embedding) slides

    Time frame: 10 years

    Identification of the biomarkers of new cancer therapies for head and neck

Secondary outcomes

  1. Characterization of the biomarkers of new cancer therapies for head and neck cancer on the patient-derived xenografts with genetic techniques

    Time frame: 10 years

    Characterization of the biomarkers of new cancer therapies for head and neck cancer on the patient-derived xenografts with genetic techniques

Study contacts

Contact information is provided by the study sponsor or research team.

Aline Gillain, MedSciences

CONTACT

[email protected]

00322764 ext. 5498

Sandra Schmitz, MD, PhD

CONTACT

[email protected]

00322764 ext. 5470

Sponsors and collaborators

Lead sponsor

Cliniques universitaires Saint-Luc- Université Catholique de Louvain

Other

Registry information

Official study title

Establishment of Primary Patient-derived Xenograft Models of Tumor From Patients With Head and Neck Cancer for Preclinical Evaluation of Targeted Therapies.

Acronym: UCL-Xenog

Important dates

Study start
2015
Primary completion
2025
Study completion
2025
First posted
Oct 9, 2015
Registry last updated
Dec 3, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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