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OpenTrials
Completed

NCT Number: NCT05392062

Pathophysiology of Gas Exchange and Time Course Changes in Spontaneously Breathing Patients With Acute Respiratory Failure Due to COVID-19. A Multicenter Prospective Study.

The pathophysiology of SARS-COV-2 related respiratory disease is still poorly understood, especially in its most severe form called acute respiratory distress syndrome (ARDS). In this case, very few studies have investigated changes in gas exchange during COVID-19 progression in spontaneously breathing patients. The investigators purpose in this study to explore the pathophysiology of gas exchange and time course changes in spontaneously breathing patients with acute respiratory failure due to COVID-19. Moreover, our aim is to identify early markers associated with worsening respiratory failure and requiring endotracheal intubation.

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Key information

Conditions

Respiratory Insufficiency COVID-19 Coronaviridae Infections Coronavirus Infections Infections Lung Diseases Nidovirales Infections Pneumonia Pneumonia, Viral RNA Virus Infections Respiration Disorders Respiratory Distress Syndrome Respiratory Tract Diseases Respiratory Tract Infections Virus Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Damien JOLLY

Reims, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with a COVID-19 confirmed infection.
  • Admission in intensive care unit for an acute respiratory failure requiring oxygen flow above 6l/min by facial mask.
  • Presence of an arterial catheter for blood sampling.

Exclusion criteria

  • Patients on mechanical ventilation on admission to the ICU.
  • Patients requiring immediate intubation on admission.
  • Patients admitted to the ICU for more than 48 hours at the time of inclusion.
  • Pulmonary embolism diagnosed before admission to the ICU.
  • Minor patients
  • Pregnant women
  • Patients under curatorship or guardianship
  • Persons deprived of liberty by a judicial or administrative decision

Treatment and study plan

Pathophysiology of gas exchange

Other

Exploration of pathophysiology of gas exchange

Primary outcomes

  1. Association between measurement of intrapulmonary right-to-left shunt, ventilatory ratio and need to intubation.

    Time frame: Lenght of hospital stay in intensive care unit

    From date of admission in intensive care unit (ICU) until the date of death or disharge from ICU, assessed up to 90 days

Secondary outcomes

  1. Association between measurement of intrapulmonary right-to-left shunt, ventilatory ratio and mortality at D90.

    Time frame: Day 90

    No provided

  2. Association between measurement of intrapulmonary right-to-left shunt, ventilatory ratio and mortality at D28.

    Time frame: Day 28

    No provided

  3. Association between intrapulmonary right-to-left shunt, ventilatory ratio with percentage of lung damage on chest CT-scan.

    Time frame: At admission

    No provided

Sponsors and collaborators

Lead sponsor

CHU de Reims

Other

Registry information

Acronym: COVAQ

Important dates

Study start
2021
Primary completion
2023
Study completion
2023
First posted
May 26, 2022
Registry last updated
Dec 13, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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