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NCT Number: NCT03541525

Pathophysiological Explorations of Red Blood Cells

GR-Ex is a program labelled by Labex (Laboratory of Excellence) by the French Ministry of Higher Education and Research. This program aims to develop the means to improve knowledge in the physiology and pathologies of erythropoiesis, red blood cells and iron metabolism, and to develop new therapeutic protocols capable of providing added value in terms of innovation.

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Key information

Conditions

Red Blood Cell Disorder

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU Hôpital de la Mère et de l'enfant Lagune, Cotonou, Benin

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Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • To be affected or have a family history of disease bound to the red blood cell,
  • For adult subjects, have signed an informed consent form,
  • For minor or major under legal safeguard subjects, the form must be signed by both parents (for minors) or by the legal representative,
  • Be affiliated to health insurance.

Exclusion criteria

  • Being deprived of freedom

Treatment and study plan

Biological sampling

Other

Biological samples including blood, surgical remainder, urine,...

Primary outcomes

  1. Innovative markers of spleen fonctionality

    Time frame: 20 years

    Retention rate (%) of red blood cells using Microsphiltration compared with non affected subjects

  2. Quantification of inflammation in sickle cell disease

    Time frame: 20 years

    Activation rate of circulating mastocytes (%)

  3. Markers of post-artesunate hemolysis

    Time frame: 20 years

    Concentration of pitted red blood cells at day 3

  4. Correlation between transfusion yield and the storage of red blood cell bags

    Time frame: 20 years

    Increasing in haemoglobin concentration at 6 hours post transfusion

  5. Efficiency of Phosphodiesterase inhibitor on neutrophil adhesion in Sickle cell disease

    Time frame: 20 years

    Proportional change in adhesion rate (%) of neutrophils measured in the peripheral blood before and after treatment with phosphodiesterase inhibitors

  6. Quantification of mitochondria removal during erythropoiesis in SDC patients, consequences on the mature RBC

    Time frame: 20 years

    Mitochondria rate and level of ROS in RBC measured by Flow Cytometry

  7. Study of iron metabolism in Diamond-Blackfan Anemia patients

    Time frame: 20 years

    Dosage of iron metabolism parameters

Study contacts

Contact information is provided by the study sponsor or research team.

Pierre Buffet, MD

CONTACT

[email protected]

+33142754456

Sandra Manceau, PhD

CONTACT

[email protected]

+33171196435

Sponsors and collaborators

Lead sponsor

Imagine Institute

Other

Registry information

Acronym: GR-Ex

Important dates

Study start
2017
Primary completion
2037
Study completion
2037
First posted
May 30, 2018
Registry last updated
Apr 30, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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