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NCT Number: NCT07661524

Passive Versus Active Music Therapy Parkinson's Disease

The purpose of this pilot study is to identify the effects of active versus passive music therapy on functional ability and psychophysiological responses to goal-directed exercise in people with Parkinson's disease.

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Key information

Age range

50 year–89 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Alabama at Birmingham

Birmingham, Alabama, 35294, United States

Location contact

Alexandra Evancho, DPT

SUB_INVESTIGATOR

Christopher G Ballmann, PhD

CONTACT

[email protected]

2059750613

Christopher G Ballmann, PhD

PRINCIPAL_INVESTIGATOR

Jane Allendorfer, PhD

SUB_INVESTIGATOR

CONTACT

[email protected]

About this study

Using a crossover counterbalanced approach, participants with idiopathic PD (n=28) will be recruited to complete 3 separate experimental visits each with a differing condition: 1) No music (control; CON), 2) PMT, 3) AMT. For each condition, participants will complete a battery of functional testing (sit-to-stand test; STS) and goal-based exercise (6-minute walk test; 6MWT) separated by 20-minutes of rest. Functional ability will be determined via biomechanical parameters (i.e. peak force, braking force, rate of force development) during the 5-time STS test. Exercise capacity (i.e. distance, average walking velocity) will be determined for goal-based exercise during the 6MWT. During each test, a medical grade smartwatch will record psychophysiological (i.e. heart rate, metabolic equivalents, electrodermal activity) responses. Furthermore, psychometric testing for motivation, enjoyment, psychological arousal, fatigue, and rating of perceived exertion will be conducted after each test attempt.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Formal diagnosis of idiopathic PD
  • Hoen & Yahr Stage <III
  • Middle or old age onset of PD (at least 50 years of age)
  • The ability to ambulate without assistive devices
  • Stable medication regimen for four weeks prior to participation
  • No changes to treatment of PD in the last month.

Exclusion criteria

  • Primary psychiatric disease (non-PD related)
  • Reports of falling in the last six weeks
  • Any reason a participant or their healthcare team believed their participation in the study could negatively impact their well-being.

Treatment and study plan

Passive music therapy

Behavioral

Listening to self-selected music

Active music therapy

Behavioral

Structured music therapy with a licensed music therapist

Primary outcomes

  1. Average time sit to stand

    Time frame: Week 1, Week 2

    Time to complete 5 sit to stand test

  2. Total walking distance accumulated in 6 minutes

    Time frame: Week 1, Week 2

    Total distance in meters accumulated during a six minute walk test

  3. Total motivation level

    Time frame: Week 1, Week 2

    Motivation levels as assessed by a visual analog scale on 0 to 100 where 0 equals the absence of motivation and 100 indicates extremely motivated

Study contacts

Contact information is provided by the study sponsor or research team.

Christopher G Ballmann, PhD

CONTACT

[email protected]

205-975-0613

Sponsors and collaborators

Lead sponsor

University of Alabama at Birmingham

Other

Collaborators

  • Rooted Music Therapy

Registry information

Official study title

Effects of Active Versus Passive Music Therapy on Functional Ability and Psychophysiological Responses to Goal-Directed Exercise in People With Parkinson's Disease

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Jun 22, 2026
Registry last updated
Jun 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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