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NCT Number: NCT06439017

Passive Thoughts in Functional Movement Disorders

Passive thoughts also known as mind-wandering are the thoughts that are not produced from the current task. When we aren't focused on a task that needs our full attention, our minds tend to drift from one thought to another. It is believed that mind wandering is the baseline or natural state of the mind, and we shift our focus only when needed for a task. Many areas of the brain are active during mind-wandering, and these areas together are called the brain's default network. An important part of this network is the right temporoparietal junction.

Functional movement disorder (FMD) is characterized by unusual movements or walking difficulties that are not caused by a specific brain or nerve injury. Functional movement disorders are believed to be caused due to loss of sense of agency. The sense of agency is the awareness that one is responsible for their own actions. The brain network involved in the sense of agency is mainly located in the right side of the brain, especially in the right temporoparietal junction. In FMD patients, there is decreased connectivity between the right temporoparietal junction and other brain areas that control movement.

Since both passive thoughts (mind wandering) and the sense of agency involve the temporoparietal junction, and because the sense of agency is abnormal in functional movement disorders (FMD), we plan to study passive thoughts in individuals with FMD. The study aims to find out how passive thoughts differ between individuals with FMD and healthy individuals. Passive thoughts will be measured using Mind Excessively Wandering Scale (MEWS).

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Aditya Murgai

London, Ontario, N6A5A5, Canada

About this study

To evaluate passive thoughts in functional movement disorders (FMD), we will collect data from 30 FMD patients and 30 healthy controls. Patients will be recruited from the movement disorders clinic and the integrated functional movement disorders clinic at LHSC. Both groups will be asked to complete the paper-based Mind Excessively Wandering Scale (MEWS) to evaluate passive thoughts. Additionally, FMD patients will complete the World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0), a 36-item self-administered questionnaire designed to measure disability over the past 30 days. Completing both questionnaires will take approximately 15-20 minutes. The questionnaires will be completed once.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

for cases:

  • Diagnosed with a functional movement disorder by the neurologist.
  • Able to understand and read English.

Exclusion criteria

for cases:

  • Unable to understand and read English.
  • Diagnosed with dementia.

Treatment and study plan

Questionaire

Other

The study will involve completing the Mind Excessively Wandering Scale (MEWS) and World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0), a 36-item self-administered questionnaire.

Primary outcomes

  1. Passive thoughts questionnaire

    Time frame: Day 1

    The Passive Thoughts Questionnaire assesses the severity of passive thoughts and their impact on daily life.

Sponsors and collaborators

Lead sponsor

Western University, Canada

Other

Registry information

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
Jun 3, 2024
Registry last updated
Jan 24, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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