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Completed

NCT Number: NCT03639376

Passive Smoking and LL-37 in Children

This study investigates the salivary LL-37 in passive smoking-exposed and unexposed children and the association between salivary LL-37 levels and periodontal clinical parameters in these children.Unstimulated salivary samples were collected from 180 children (90 passive smoking-exposed and 90 passive smoking-unexposed)

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Key information

Conditions

Innate Immunity Periodontal Health

Age range

6 year–12 year

Sex eligibility

All sexes

Study type

Observational

About this study

Diverse mechanisms conduce to the detrimental periodontal effects of passive smoking, including alteration of both microbial and host response factors.

Antimicrobial peptides are considered to be an important intermediate step in initiating an initial immune response against the microbial side of the oral gingival epithelium and in the transition to acquired immunity.

LL-37 has a wide antimicrobial activity against both cariogenic and periopathogenic bacteria and its role in maintaining oral health has recently been stated

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Systemically healthy children

Exclusion criteria

  • Any medications known to affect defense system and periodontium
  • The presence of orthodontic / intraoral appliance

Treatment and study plan

Primary outcomes

  1. Antimicrobial Peptide

    Time frame: In the first 18 months of study

    LL-37 (pg/mL)

Secondary outcomes

  1. Passive smoking measurement

    Time frame: In the first 18 months of study

    Cotinine (ng/mL)

Sponsors and collaborators

Lead sponsor

Kırıkkale University

Other

Registry information

Official study title

Salivary LL-37 and Periodontal Health in Children Exposed to Passive Smoking

Important dates

Study start
2016
Primary completion
2018
Study completion
2018
First posted
Aug 21, 2018
Registry last updated
Aug 21, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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