Skip to main content
OpenTrials
Completed

NCT Number: NCT02977390

Passive Leg Raise Induced Stroke Volume Changes in Elderly Prior to Elective Surgery Measured by LiDCOplusTM

This is a pilot study to investigate whether patients at advanced age are fluid responders via a reversible fluid challenge, the passive leg raise test. This will be measured with a non-invasive cardiac output monitor, the LiDCO (LiDCO Hemodynamic monitoring) .

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Stroke Volume Cardiovascular System Fluid Therapy

Age range

80 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Karolinska University Hospital

Huddinge, 14186, Sweden

About this study

The intervention is as simple as a passive leg raise with measurement of effect on Stroke volume.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients ≥80 years of age, undergoing elective urologic surgical procedure

Exclusion criteria

  • age <80 years, severe aortic insufficiency, first case of the day on the operation program, unavailability of research personnel and contraindication to Lithium.

Treatment and study plan

Passive leg Raise

Other

By tilting the patient's bed from sitting 45 degrees to supine with legs tilted up 45 degrees we recruit the blood volume in the legs and can measure a reversible fluid challenge on stroke volume.

Primary outcomes

  1. Assess passive leg raise responsiveness in spontaneously breathing aged patients.

    Time frame: Within 1 minute of the intervention

    Stroke volume changes in ml and as per cent change compared to baseline

Secondary outcomes

  1. Investigate whether there is an association between a positive response to passive leg raise on stroke volume and post spinal anesthesia.

    Time frame: 30 minutes

    Post spinal bloodpressure per cent change or 30 mmHg decrease

Sponsors and collaborators

Lead sponsor

Karolinska Institutet

Other

Registry information

Official study title

Passive Leg Raise Induced Stroke Volume Changes in Elderly Prior to Elective Surgery Measured by LiDCOplusTM to Guide Fluid Therapy

Important dates

Study start
2013
Primary completion
2015
Study completion
2015
First posted
Nov 30, 2016
Registry last updated
Dec 1, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.