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NCT Number: NCT07393061

Partial Wrist Denervation in Comminuted Articular Distal Radius Fractures

the aim of Partial Wrist Denervation in Comminuted articular Distal Radius Fractures is to decrease incidence of chronic wrist pain follwing this type of fracture

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Assiut Universty

Asyut, 22222, Egypt

About this study

Distal radius fractures represent the most common fractures in adults showing an overall prevalence of 17.5 % with respect to all fractures. partial wrist denervation is an adjunctive procedure performed during initial fracture fixation to mitigate chronic pain by interrupting sensory innervation to the wrist joint. It targets the anterior interosseous nerve (AIN) and posterior interosseous nerve (PIN), which convey nociceptive signals from the radiocarpal and midcarpal joints.

Comminuted intra-articular distal radius fractures (AO/OTA Type C2/C3) often lead to post-traumatic arthritis due to articular incongruity and capsular damage. Denervation at the index procedure may reduce central sensitization and chronic pain by resecting afferent pain fibers, potentially improving postoperative rehabilitation and functional outcomes.

Acute comminuted intra-articular distal radius fractures (AO/OTA C2/C3) with high risk of post-traumatic arthritis (e.g., articular step-off >2 mm, severe fragmentation).

  • Active individuals seeking motion preservation, those with high functional demands (e.g., athletes, laborers), or patients preferring a less invasive option than salvage procedures.
  • Adjunct to primary fixation: Performed concurrently with volar locking plate (VLP) or dorsal plating.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

• Age from 18

  • Fracture Pattern: Acute, comminuted intra-articular distal radius fractures (AO/OTA Type C2 or C3).
  • Surgical Context: Procedure performed as a primary adjunct during initial open reduction and internal fixation (ORIF).

Exclusion criteria

Active local infection over the surgical site.

  • Compromised soft tissue envelope that precludes safe dissection.
  • Vascular injury or compromise requiring repair.
  • Pre-existing neurological deficit (e.g., complex regional pain syndrome, major peripheral nerve injury).

Treatment and study plan

Partial Wrist Denervation in Comminuted articular Distal Radius Fractures

Procedure

Partial Wrist Denervation in Comminuted articular Distal Radius Fractures through sme approach of the surgery

Primary outcomes

  1. The end results PAIN will be assessed according to mayo clinc wrist score

    Time frame: 2 weeks, 6 weeks, 3 months, 6 months..and 1 year

    mayo clinc wrist score its a clincal reported outcome measure designed to assess function and pain of the wrist follwing surgery the score is bassed on 100 points divided into four equally weighted categories the final score places the wrist into outcome category total score 90/100 is excellent while below 65 is poor

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Feb 6, 2026
Registry last updated
Feb 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.