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Completed

NCT Number: NCT02149641

Parotid-sparing IMRT for Nasopharyngeal Cancer

In the treatment of nasopharyngeal cancers, to determine the incidence of high grade (≥G2) subjective xerostomia at 1 year.

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Key information

Conditions

Nasopharyngeal Cancers Head and Neck Neoplasms Intensity Modulated Radiotherapy With Chemotherapy Nasopharyngeal Diseases Nasopharyngeal Neoplasms Neoplasms Neoplasms by Site Otorhinolaryngologic Diseases Otorhinolaryngologic Neoplasms Pharyngeal Diseases Pharyngeal Neoplasms Stomatognathic Diseases

Age range

16 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

The Royal Marsden NHS Foundation Trust

London, SW3 6JJ, United Kingdom

About this study

The purpose of this study was to determine the feasibility in delivering induction chemotherapy and concomitant chemotherapy with IMRT in the treatment of locally advanced nasopharyngeal cancers and to determine the incidence of high grade (≥G2) subjective xerostomia at 1 year.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • nasopharyngeal cancers

Exclusion criteria

  • Patients <16 years old or with a previous malignancy other than non-melanomatous skin cancer were excluded

Treatment and study plan

Intensity modulated radiotherapy with chemotherapy

Radiation

Primary outcomes

  1. the incidence of ≥G2 xerostomia at 1 year using the subjective component LENTSOMA

    Time frame: 12 months

Secondary outcomes

  1. Acute radiation toxicities

    Time frame: 0-3 months

  2. Late radiation toxicities

    Time frame: 3-24 months

  3. loco-regional disease-free survival (LRDFS), progression-free survival (PFS) and overall survival (OS)

    Time frame: 2 years

  4. chemotherapy compliance and toxicities

    Time frame: 0-12 weeks

Sponsors and collaborators

Lead sponsor

Royal Marsden NHS Foundation Trust

Other

Registry information

Official study title

Phase II Study of Parotid Sparing IMRT for Nasopharyngeal Cancer

Important dates

Study start
2006
Primary completion
2011
Study completion
2012
First posted
May 29, 2014
Registry last updated
May 29, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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