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Completed

NCT Number: NCT05152706

Parkinson´s Disease, Aerobic Exercise and Photobiomodulation

The aim of the present study was to assess the effects of a combined therapy of aerobic exercise and transcranial photobiomodulation upon the cardinal motor sympomts of Parkinson´s disease of a group of Parkinson´s disease patients. It was hypothesized that aerobic exercise and transcranial photobiomodulation would yield significant benefits in the cardinal motor sympomts of the illness.

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Key information

Conditions

Parkinson Disease Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Movement Disorders Nervous System Diseases Neurodegenerative Diseases Parkinsonian Disorders Synucleinopathies

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Physical Education and Sport, University of León

León, Castille and León, 24071, Spain

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosis with idiopathic PD and rated 1-2 on the Hoehn and Yahr Scale.
  • No type of dementia as assessed by the mini-mental state examination.
  • Able to stand for 2 min without assistance.
  • Able to walk 10 m without assistance.

Exclusion criteria

  • Individuals were excluded if they suffered a neurological disease other than PD, if the subject has an implant of any kind in the head (e.g., stent, clipped aneurysm, embolized arteriovenous malformation, implantable shunt - Hakim valve) or if they did not meet the eligibility criteria.

Treatment and study plan

Aerobic training

Other

Cycling at the aerobic intensity

Photobiomodulation

Other

Photons therapy

Primary outcomes

  1. MDS-UPDRS

    Time frame: 6 months

    The motor portion of the Movement Disorder Society-Unified Parkinson´s (MDS-UPDRS, the minimum and maximum values are 0 and 72, respectively and the higher score, the worse patient condition)

Secondary outcomes

  1. DASH

    Time frame: 6 months

    The disabilities of the arm, shoulder and hand (DASH, the minimun and maximum values are 0 and 190, respectively and the higher score, the worse patient condition)

  2. Static posturography

    Time frame: 6 months

    The centre of pressure (CoP) parameters (these CoP parameters; Length, in mm, Area in mm2 and Speed, Xspeed and Yspeed in m/s will be combined to report the static posturography)

  3. TMWT

    Time frame: 6 months

    10 meters walking test (speed in seconds)

  4. TUG

    Time frame: 6 months

    Time up Go Test (speed in seconds)

  5. Grip strength

    Time frame: 6 months

    Grip strength in kg

Sponsors and collaborators

Lead sponsor

University of Oviedo

Other

Registry information

Official study title

Parkinson´s Disease, Aerobic Exercise and Photobiomodulation: a Randomised Controlled Trial

Acronym: PDAERPBM

Important dates

Study start
2021
Primary completion
2024
Study completion
2024
First posted
Dec 10, 2021
Registry last updated
Dec 6, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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