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NCT Number: NCT07207850

Parents Helping Parents for Youth Vaping Cessation

The goal of this randomized controlled study is to test if this new intervention works to help adolescents quit vaping. A key feature of the program is the use of peer support for parents, delivered by trained parent coaches. Participants will complete baseline and follow up surveys. Parents in the intervention arm will receive peer support as part of the program.

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Key information

Age range

15 year–18 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Nebraska Medical Center

Omaha, Nebraska, 68198-4375, United States

Location status: Recruiting

Location contact

Daisy Dai, PhD

CONTACT

[email protected]

4025595907

About this study

This objective of study is to develop and test the feasibility of a novel Parents-helping-Parents for Youth Vaping Cessation (PhP-VX) program. The investigators will conduct a feasibility pilot test with 100 parent-adolescent dyads recruited from an EHR system. Half of the dyads will receive the "PhP-VX" program for 3 months, and half of the dyads will be assigned to the control (no-treatment) group.

The PhP-VX program consists of two key components: 1) online lessons for participating parents and adolescents and 2) one on one sessions with a coach for parents.

Eligible dyads will be randomly assigned to either the test or control group using a computer-generated randomization list. At baseline, all participants will complete a survey assessing their e-cigarette and tobacco use, vaping knowledge, and exposure to marketing and media. Dyads assigned to the test arm will receive PhP-VX program instructions, and parents will be immediately connected with a coach. Parents will be scheduled to receive six bi-weekly, 30-minute, 1:1 coach-facilitated sessions via Zoom. The coaches will identify the priority needs of the participant, provide support and advocacy (e.g., coach on how to identify own needs and access resources), role model (e.g., share experiences, demonstrate effective decision-making), effective communication with their children, and facilitate change (motivation, facilitate change through goal setting/education/skills building). Parents will also be able to contact the coach as needed for additional support and resources.

All participants in both the control and test arms will be followed up at months 1, 3, and 6 with questions on e-cigarette use, vaping knowledge, and marketing/media literacy. Parents and children in the test arm will also complete an evaluation of the PhP-VX program at the end of the intervention (month 3).

The investigators will offer twenty adolescent participants (10 control, 10 intervention) the option to provide saliva samples at baseline, 3 months, and 6 months. The samples will be collected using the iScreen Oral Fluid Device (OFD) cotinine test, which detects cotinine, a metabolite of nicotine and the recommended biomarker for validating self-reported tobacco abstinence. Cotinine levels will serve as our biochemical verification of participants' self-reported abstinence. Adolescents who agree to participate will receive saliva collection kits by mail. Participants will be instructed to upload a photo of their test result via a REDCap survey.

Parents and children in the control group, who receive no intervention during the study, will be given access to online training materials at the completion of the study.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

ADOLESCENT INCLUSION:

  • 15-18
  • Report vaping in the previous 30 days
  • English literacy

PARENT INCLUSION:

  • Biological, adoptive, stepparents, or adult guardian of adolescent participating
  • Have face-to-face contact with the adolescent at least one day per week during the study period
  • Access to a computer or mobile phone at home
  • Interested in helping adolescent quit e-cigarette/vape use

Treatment and study plan

Parents Helping Parents program

Behavioral

Our innovative vaping cessation program will include two key components: 1) online training for parents and their offspring, and 2) parent-helping-parent coach sessions. Parents and children in the control setting will receive no treatments during the intervention (Baseline to Month 3). Dyads will be provided online training materials at the end of the study.

Primary outcomes

  1. 7-day point prevalence abstinence

    Time frame: Baseline and Follow ups (1 month, 3 months, 6 months)

Secondary outcomes

  1. Vaping frequency

    Time frame: Baseline and Follow ups (1 month, 3 months, 6 months)

  2. Past 7 day Vaping intensity

    Time frame: Baseline and Follow ups (1 month, 3 months, 6 months)

    Self-reported vaping intensity will be assessed with the questions "In the past 7 days, on the days you vaped, how many times did you usually pick up your device to vape? "and "In the past 7 days, each time you pick up your vape, how many puffs do you usually take before putting it away?".

  3. Other tobacco use

    Time frame: Baseline and Follow ups (1 month, 3 months, 6 months)

Study contacts

Contact information is provided by the study sponsor or research team.

Daisy Dai, PhD

CONTACT

[email protected]

402-559-5907

Sponsors and collaborators

Lead sponsor

University of Nebraska

Other

Collaborators

  • Massachusetts General Hospital
  • National Cancer Institute (NCI)

Registry information

Official study title

Parents Helping Parents for Youth Vaping Cessation (PhP-VX)

Acronym: PhP-VX

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Oct 6, 2025
Registry last updated
May 26, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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