Skip to main content
OpenTrials
Recruiting

NCT Number: NCT07219992

Parent-Based Treatment for Adolescent Anxiety

This study aims to test the efficacy of a parent-only approach to treating anxiety disorders in adolescents: SPACE (Supportive Parenting for Anxious Childhood Emotions). The comparator is another parent-based approach, PES (Parent Education and Support). The study design is a randomized controlled trial with 2 treatment arms and 3 assessment points (pre, post, and follow-up) using questionnaire data and clinical interviews.

Recruiting

Interested in participating?

Request Info

Key information

Age range

14 year–17 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Yale Child Study Center

New Haven, Connecticut, 06519, United States

Location status: Recruiting

Location contact

Rebecca Etkin, PhD

CONTACT

[email protected]

203-737-4644

About this study

The primary objective is to examine if SPACE is more efficacious than PES in reducing adolescent anxiety symptoms. The secondary objective is to examine if SPACE produces greater change than PES in improving family accommodation and family functioning.

SPACE and PES will be delivered over 12 sessions: Sessions 1-6 (once weekly), a mid-treatment assessment, Sessions 7-12 (once weekly), and a Post-treatment assessment.

Sessions can be attended in person or via Zoom.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Meet criteria for a primary DSM-5 AD, including separation anxiety disorder, social anxiety disorder, generalized anxiety disorder, specific phobia, panic disorder, and agoraphobia (determined by the ADIS-C/P).
  • Cease all other psychosocial treatment, upon consultation with the project staff and service provider.
  • Not currently use any psychotropic medication, other than a stable dose (i.e., same dose for a minimum of 6 months prior to enrollment; no changes during course of the study) of a stimulant medication or selective serotonin reuptake inhibitor (SSRI).
  • Have an eligible and willing participating parent (see parent exclusions below).

Exclusion criteria

Adolescent:

  • Meet criteria for any DSM-5 disorder more impairing than the most impairing AD (determined by the ADIS-C/P).
  • Have any of the following disorders: autism spectrum disorder; intellectual disability; neurocognitive disorders; bipolar disorder; schizophrenia and other psychotic disorders; and alcohol and substance use disorders (determined by the Health History Form and ADIS-C/P).
  • Report a suicide attempt in the last 3 months, or current suicide intent and plans (determined by the ASQ).
  • Be a victim of past or present undisclosed abuse requiring investigation or ongoing supervision by the Department of Social Services.
  • Not have sufficient proficiency with the English language to complete assessments.

Parents:

  • Have any of the following: intellectual disability; neurocognitive disorders; untreated bipolar disorder; untreated schizophrenia and other psychotic disorders; and untreated alcohol and substance use disorders (determined by the Health History Form).
  • Not be living with the adolescent at least 50% of the time for at least one year prior to enrollment.
  • Not have sufficient proficiency with the English language to complete assessments and treatment.

Treatment and study plan

Supportive Parenting for Anxious Childhood Emotions (SPACE)

Behavioral

Parent based treatment delivered by a therapist 12 weekly sessions with parents.

Parent Educational Support (PES)

Behavioral

Parent Educational Support: 12 weekly sessions with parents

Primary outcomes

  1. Mean Pediatric Anxiety Rating Scale (PARS) score

    Time frame: Week 1 and 14

    This scale measures anxiety symptoms on 7 dimensions (e.g., avoidance, severity) from 0 ("minimal") to 5 ("extreme"). Total scores range from 0 - 35. Higher scores indicate greater anxiety severity.

  2. Mean Screen for Child Anxiety Related Emotional Disorders (SCARED-C/P) score

    Time frame: Week 1, 7 and 14

    This scale assesses adolescent anxiety symptoms on a 3-point scale (0 "not true/hardly ever true" to 2 "very true/often true") with total score range = 0 - 82. Higher scores suggest greater anxiety symptoms.

  3. Mean Child Anxiety Impact Scale (CAIS-C/P) score

    Time frame: Week 1 and 14

    This scale assesses adolescent anxiety that specifically captures impairment related to anxiety across important domains of functioning. Adolescents and parents rate items on a 4-point scale (0 "not at all" to 3 "very much"); total score range = 0 - 81. Higher scores suggest greater anxiety symptoms.

  4. Clinical Global Impression Scale - Severity (CGI-S) and Improvement (CGI-I) scales score

    Time frame: Week 1 and 14

    This measure will be used to assess overall severity (CGI-S) and improvement (CGI-I) in adolescent anxiety. Total score range for each is 1-7. (Scores of 1 ("very much improved/normal") or 2 ("much improved/borderline ill") indicate a positive treatment response; all other responses are considered negative responses. Higher scores indicate worse outcome.

Secondary outcomes

  1. Mean Family Accommodation Scale - Anxiety (FASA-C/P) score

    Time frame: Week 1, 8 and 14

    This scale assesses family accommodation. Adolescents and parents rate 9 items on a 5-point scale, 0 "never" to 4 "daily"; total score range = 0 - 36. Higher scores indicate more accommodation.

  2. Mean Family Assessment Device - General Functioning Scale (FAD-GF) score

    Time frame: Week 1 and 14

    This scale will measure of overall family functioning. Adolescents and parents rate 12-items on a 4-point scale (0 "strongly disagree" - 3 "strongly agree"). Total score range 0-3. Higher scores indicate more unhealthy family functioning.

  3. Mean Parent Problem Checklist scale score

    Time frame: Week 1 and 14

    This scale will measure co-parenting and assesses parents' ability to cooperate and work together in family management. Parents rate 16 items on a yes/no scale to form the Overall Problems scale, total score range = 0 - 16. Higher scores indicate greater conflict. Parents also rate each "yes" on a 7-point scale (1 "not at all" to 7 "very much") to form the Extent scale. Total score range 16-112. Higher scores indicate greater extent of a problem for them and their partner.

  4. Mean Parent Behavior Inventory - Child and Parent Report (CRPBI/PRPBI) scale score

    Time frame: Week 1 and 14

    This scale will measure parent-child relationship quality. Adolescents and parents respectively rate 30-items assessing perceived parental behaviors on a scale from 0 ("Not like") to 2 ("A lot like"). Total score range = 0 to 2 with higher scores indicating better relationship quality.

Study contacts

Contact information is provided by the study sponsor or research team.

Alison Magnotti, MA

CONTACT

[email protected]

203-737-4644

Rebecca Etkin, PhD

CONTACT

[email protected]

203-737-4644

Sponsors and collaborators

Lead sponsor

Yale University

Other

Collaborators

  • MQ: Transforming Mental Health

Registry information

Official study title

Testing a Novel Parent-Based Treatment for Adolescent Anxiety Disorders

Important dates

Study start
2025
Primary completion
2028
Study completion
2028
First posted
Oct 23, 2025
Registry last updated
Nov 21, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.