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NCT Number: NCT07143695

Parasternal Intercostal Muscle Thickening as an Additive Weaning Criterion

Increased days of MV are not without hazards, including barotraumas and ventilator-associated pneumonia. Similarly, premature separation of MV is associated with increased mortality secondary to adverse cardiorespiratory events. Therefore, the time of weaning should be wisely evaluated. There is growing evidence concerning respiratory muscles dysfunction that contributes to difficulty or prolonged liberation from MV.

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Key information

Conditions

Critically Ill Critical Illness Disease Attributes Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Cairo University

Cairo, Giza Governorate, 6890, Egypt

Location status: Recruiting

Location contact

Mina Helmy

CONTACT

[email protected]

01275716942

About this study

Researchers aim to evaluate the influence of adding parasternal thickening fraction to the standard weaning criteria and its impact on reintubation

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • critically ill patient mechanically ventilated for 24 hours or more first spontaneous breathing trial

Exclusion criteria

  • patient refusal difficult ultrasound views tracheostomized patient neuromuscular disorders

Treatment and study plan

Parasternal intercostal thickening fraction

Device

Parasternal intercostal thickening fraction less than 6.5%

Sham parasternal intercostal thickening

Device

Ultrasound assessment only for purpose of blinding

Primary outcomes

  1. Incidence of reintubation

    Time frame: Within 72 hours after extubation

    need for reintubation

Secondary outcomes

  1. Incidence of weaning failure

    Time frame: within 72 hours post-extubation

    failed spontaneous breathing trial or reintubation

Study contacts

Contact information is provided by the study sponsor or research team.

Cairo university

CONTACT

[email protected]

+201275716942

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Parasternal Intercostal Muscle Thickening as an Additive Weaning Criterion to Minimize Re-intubation Rate: a Randomized Controlled Trial

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Aug 27, 2025
Registry last updated
Sep 8, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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