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NCT Number: NCT06516432

Parasternal Blockade and Serum Lactate in Cardiac Surgery

Serum lactate level is a key indicator of tissue perfusion. Parasternal blockade is associated with reduced postoperative inflammatory response by inhibiting stress response, leading to better outcomes. Elevated lactate levels help identify patients at risk of postoperative morbidity and mortality. This analytical cross-sectional study evaluated the association between parasternal blockade and serum lactate levels in patients undergoing elective cardiac surgery in 2022 at Specialty Hospital CMNO. Patients with and without parasternal block were compared for changes in serum lactate levels during and after anesthesia within the first 24 hours.

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Key information

Conditions

Elective Cardiac Surgery

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Centro Médico Nacional de Occidente

Guadalajara, Jalisco, 44329, Mexico

Location status: Recruiting

Location contact

Alejandro González Ojeda, PhD

CONTACT

[email protected]

3336683000

About this study

Background: Serum lactate level is a crucial indicator of tissue perfusion. Parasternal blockade has been related to a reduction of the postoperative inflammatory response, by inhibition of the stress response, leading to a better prognosis. Increased lactate level is a useful parameter in the identification of patients at risk of postoperative morbidity and mortality.

Objective: To evaluate the association between parasternal blockade and serum lactate level in patients undergoing cardiac surgery, both trans and postanesthesia.

Materials and Methods: Analytical cross-sectional study in adult patients undergoing elective cardiac surgery during the year 2022 in Specialty Hospital CMNO, patients with and without application of parasternal block were analyzed, and it was associated with changes in serum lactate level trans and post anesthesia in the first 24 hours. Approval registration: R-2023-1301-024.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients older than 18 years
  • Either sex
  • ASA II-III
  • Patients who underwent cardiac surgery with median sternotomy and use of cardiopulmonary bypass.

Exclusion criteria

  • Patients with pre-existing conditions that could independently affect serum lactate levels.

Treatment and study plan

parasternal block

Procedure

In the case-control groups, patients with elevated serum lactate levels above 2 mmol/L and those who remained below this limit will be identified.

Requirement of total dose regarding fentanyl

Procedure

In case-control groups, obtain measurement of total postoperative fentanyl requirement.

Primary outcomes

  1. Serum lactate measurement

    Time frame: 24 hours postoperative

    Elevated serum lactate levels above 2 mmol/L

Study contacts

Contact information is provided by the study sponsor or research team.

Alejandro Gonzalez, 3

CONTACT

[email protected]

3331294165

Clotilde Fuentes, 1

CONTACT

[email protected]

3331154287

Sponsors and collaborators

Lead sponsor

Instituto Mexicano del Seguro Social

Other Gov

Registry information

Official study title

Serum Lactate in the Application of Parasternal Blockade in Trans and Post Anesthetic Stages in Cardiac Surgery

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Jul 24, 2024
Registry last updated
Jul 24, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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