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Completed

NCT Number: NCT07432256

Parasternal Block Added to Serratus Anterior Plane Block in Breast Reduction Surgery

This study aims to evaluate the effect of adding a Superficial Parasternal Intercostal Plane Block (PIPB) to the Serratus Anterior Plane Block (SAPB) on postoperative pain control in patients undergoing breast reduction surgery under general anesthesia. Effective postoperative analgesia is essential to reduce opioid consumption and improve recovery.

All patients will receive standard general anesthesia. Patients will be allocated into three groups: a control group receiving no regional block, a group receiving SAPB alone, and a group receiving SAPB combined with PIPB. The primary outcome of the study is total opioid consumption within the first 24 hours after surgery. Secondary outcomes include postoperative pain scores, Quality of Recovery-15 (QoR-15) scores, and intraoperative remifentanil consumption.

The study aims to determine whether SAPB reduces postoperative opioid requirements compared to no block, and whether adding PIPB provides additional analgesic benefit by blocking the anterior cutaneous branches of the intercostal nerves. The findings may contribute to improving multimodal analgesia strategies in breast surgery.

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Key information

Conditions

Breast Reduction Agnosia Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Opioid Consumption Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Perceptual Disorders Postoperative Complications Postoperative Pain Signs and Symptoms

Age range

18 year–65 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Zonguldak Bulent Ecevit University Hospital

Zonguldak, Maltepe, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Female patients aged 18-65 years
  • Scheduled for elective breast reduction surgery under general anesthesia
  • American Society of Anesthesiologists (ASA) physical status I-III
  • Ability to understand the study and provide written informed consent

Exclusion criteria

  • Patient refusal
  • Known allergy to local anesthetics
  • Coagulopathy or ongoing anticoagulant therapy
  • Infection at the block site
  • Chronic opioid use or opioid dependence
  • Severe hepatic or renal insufficiency
  • Pregnancy or breastfeeding

Treatment and study plan

Serratus Anterior Plane Block (SAPB)

Procedure

injection local anesthetic between 5th rib and serratus anterior muscle

Serratus Anterior Plane Block (SAPB) and parasternal intercostal plane block

Procedure

both injection local anesthetic between 5th rib and serratus anterior muscle at midaxillary line and between 4th costal cartilage and pectoralis major muscle at next to the sternum

Primary outcomes

  1. Total postoperative opioid consumption in the first 24 hours

    Time frame: First 24 hours after surgery

    Total opioid consumption during the first 24 postoperative hours will be recorded and compared between the study groups.

Secondary outcomes

  1. Quality of recovery by using QoR-15 questionnaire

    Time frame: postoperative 24th hour

  2. Pain Scores

    Time frame: postoperative 0, 1, 2, 6, 12, 24 th hour

    using NRS Scale

Sponsors and collaborators

Lead sponsor

Zonguldak Bulent Ecevit University

Other

Registry information

Official study title

The Effect of Adding a Parasternal Intercostal Plane Block to a Serratus Anterior Plane Block on Postoperative Opioid Consumption in Breast Reduction Surgery

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Feb 25, 2026
Registry last updated
Feb 25, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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