CHU Clermont-Ferrand
Clermont-Ferrand, 63003, France
Completed
NCT Number: NCT01152502
Paracetamol Metabolism in Post Operative Conditions
Follow-up of urinary concentration from paracetamol metabolites by patients with aortic surgery during 4 days therapeutic intake (perfalgan ® 4 x 1g IV/day)
Completed
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Notify MeKey information
Age range
18 year and older
Sex eligibility
All sexes
Study type
Observational
Primary location
About this study
D-15 to D0: selection
- patient information and non-opposition obtained
- inclusion and non inclusion criteria check
- clinical exam
D-1 to D0 : 24 hours diuresis
D0 : operation day
Before anesthesia :
- urine collection (paracetamol metabolites dosage)
- blood sampling (glutathion and liver function test)
Surgery:
- 1st paracetamol intake before closing
- Then administration every 6 hours
D1 to D4 :
- 24 hours urine collection (metabolites dosage)
- blood sampling et D1 and D4(glutathion and liver function test)
D5 : final clinical exam
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- aortic surgery
- treatment with intraveinous paracetamol (4 grammes daily during 4 days)
- patient agrees to participate
Exclusion criteria
- - patient disagrees
- paracetamol contra-indication
- paracetamol intake 5 days before surgery
Treatment and study plan
Primary outcomes
-
Follow-up of urinary concentration from paracetamol metabolites by patients with aortic surgery during 4 days therapeutic intake (perfalgan ® 4 x 1g IV/day)
Time frame: during 4 days therapeutic intake
Secondary outcomes
-
- Follow-up of glutathion concentration during 4 post operative days
Time frame: during 4 post operative days
-
Monitoring of liver function
Sponsors and collaborators
Lead sponsor
University Hospital, Clermont-Ferrand
Other
Registry information
Important dates
- Study start
- 2008
- Primary completion
- 2008
- Study completion
- 2010
- First posted
- Jun 29, 2010
- Registry last updated
- Jun 29, 2010
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.