Recruiting

NCT Number: NCT07345949

Panniculitis in Dermatomyositis

Adipose tissue involvement is rare in dermatomyositis. The occurrence of partial or diffuse lipodystrophy is a rare but well-characterized manifestation, particularly in juvenile forms of dermatomyositis. Panniculitis, on the other hand, is exceptional and rarely described in the literature, mostly in the form of clinical cases.

Panniculitis in dermatomyositis is exceptional. There are no validated diagnostic criteria or treatment recommendations. Treatment is based, by analogy, on the therapeutic strategy for lupus panniculitis and involves synthetic antimalarials combined with steroids and/or immunosuppressants.

The aim of this study is to describe panniculitis in dermatomyositis in order to determine whether there are clinical or histological characteristics that distinguish it from other causes of panniculitis, particularly panniculitis associated with lupus erythematosus.

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Panniculitis Connective Tissue Diseases Dermatomyositis Muscular Diseases Musculoskeletal Diseases Myositis Nervous System Diseases Neuromuscular Diseases Polymyositis Skin Diseases Skin and Connective Tissue Diseases

Age range

1 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Service de dermatologie - CHU de Strasbourg - France

Strasbourg, 67091, France

Location status: Recruiting

Location contact

Dan LIPSKER, MD

PRINCIPAL_INVESTIGATOR

Dan LIPSKER, MD, PhD

CONTACT

[email protected]

33 3 88 11 50 48

Solène BARTOLOMEI, MD

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Subject aged 1 year and older
With a confirmed diagnosis of dermatomyositis
With a confirmed diagnosis of panniculitis

Exclusion criteria

Panniculitis for which another cause has been established, particularly infectious and metabolic panniculitis

Treatment and study plan

Primary outcomes

Determine the clinical and histological characteristics of panniculitis in dermatomyositis

Time frame: Up to 30 months
The investigators aim to describe:

how inflammation of the subcutaneous fat manifests
- in individuals with dermatomyositis
- both:
- clinically and visually in the patient
- under the microscope (histology)

Study contacts

Contact information is provided by the study sponsor or research team.

Dan LIPSKER, MD

CONTACT

[email protected]

33 3 88 11 50 48

Sponsors and collaborators

Lead sponsor

University Hospital, Strasbourg, France

Other

Registry information

Acronym: PANNICUL

Important dates

Study start: 2025
Primary completion: 2028
Study completion: 2028
First posted: Jan 16, 2026
Registry last updated: Jan 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Recruiting