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NCT Number: NCT06585072

Pancreatic Cancer and Diabetes Mellitus

The goal of this observational study is to learn about post-surgery of pancreatic cancer diabetes mellitus.The main questions it aims to answer are:

1. Are the incident rates of glucose metabolic disorders (pre-diabetes and diabetes mellitus) after pancreatic cancer of different etiologies the same? 2. Are alterations in endocrine and exdocrine secretory function in patients with pancreatic surgery associated with all-round outcomes? All patients with pancreatic surgery have been given the standardized treatment for the condition.

The reasearchers will summarize the incident rates of glucose metabolic disorders (pre-diabetes and diabetes mellitus) during different surgical procedures to explore the association between alternations in endocrine and exdocrine secrectory function and all-round outcomes.

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Key information

Conditions

Pancreatic Cancer Diabetes Mellitus Digestive System Diseases Digestive System Neoplasms Endocrine Gland Neoplasms Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Neoplasms Neoplasms by Site Nutritional and Metabolic Diseases Pancreatic Diseases Pancreatic Neoplasms Surgery

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Changzheng Hospital

Shanghai, Shanghai Municipality, 200003, China

Location status: Recruiting

Location contact

tuo li

CONTACT

[email protected]

13918507887

About this study

Investigators will prospectively collect data from patients with pancreatic cancer after surgery in participant centers.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • male or female Chinese subjects; 2. Age ≥ 18 years; 3. patients with pancreatic cancer who are proposed to undergo pancreatectomy by pancreaticobiliary surgery at our hospital; 4. those who voluntarily completed the Pancreatobiliary Surgery Cohort Study and signed the informed consent; 5. those who have completed and banked serum and pathological specimens at our hospital.

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Exclusion criteria

  • those with a previous history of comorbid diabetes mellitus or pre-diabetes mellitus, or preoperative HbA1C ≥ 6.0% or fasting blood glucose ≥ 6.1 mmol/l; 2. those with positive islet-associated antibodies 3. those with the presence of medications, endocrine disease exposures that can lead to a risk of secondary diabetes; 4. pregnant or nursing women; 5. Cognitive impairment or other reasons for failing to sign the informed consent form.

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Treatment and study plan

All enrolled subjects completed dynamic blood glucose monitoring to obtain continuous peripheral blood glucose data.

Diagnostic Test

All enrolled subjects completed dynamic blood glucose monitoring to obtain continuous peripheral blood glucose data.

Primary outcomes

  1. Number of Participants Who developed glucose metabolic disorders(pre-diabetes and diabetes mellitus)

    Time frame: From enrollment to five years after the end of the surgery

    The diagnosis of glucose disorders should be made applying criteria of the American Diabetes Association.

Secondary outcomes

  1. Overall Survival

    Time frame: From enrollment to five years after the end of the surgery

  2. Disease-Free Survival

    Time frame: From enrollment to five years after the end of the surgery

Study contacts

Contact information is provided by the study sponsor or research team.

Tuo Li, Doctor

CONTACT

[email protected]

86-13918507887

Sponsors and collaborators

Lead sponsor

Shanghai Changzheng Hospital

Other

Registry information

Official study title

Prospective Cohort Study on Endo-Exdo Secretory Function Alterations and All-round Outcomes After Pancreatic Cancer

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Sep 5, 2024
Registry last updated
Jul 1, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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