Recruiting

NCT Number: NCT00912717

Pancreatic Adenocarcinoma Gene Environment Risk Study

After informed consent, participants will be asked to complete a medical/family history questionnaire and provide a blood sample. Some participants may also be asked to provide a urine sample. Individuals undergoing procedures that require collection of biological samples for clinical purposes may have these samples saved for research purposes. Participants will also be asked for their permission for study investigators to access medical records and/or recontact them for updates to their medical and family histories. Data and biospecimens will be stored for potential future research projects.

Recruiting

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Key information

Conditions

Pancreatic Cancer Digestive System Diseases Digestive System Neoplasms Endocrine Gland Neoplasms Endocrine System Diseases Neoplasms Neoplasms by Site Pancreatic Diseases Pancreatic Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Pittsburgh

Pittsburgh, Pennsylvania, 15213, United States

Location status: Recruiting

Location contact

Randall E Brand, MD

CONTACT

[email protected]

412-623-3105

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Histologically confirmed or CT confirmed diagnosis of pancreatic adenocarcinoma
Subjects with abnormal imaging study (CT, MRI, MRCP, EUS)
Control subjects with a clinical diagnosis of a pancreas, liver, or intestinal condition
Control subject with acute pancreatitis
Control subject with chronic pancreatitis
Control subject with biliary obstruction
Control subject with pancreatic cyst
Member of a high risk family (≥ 1 close relative with pancreatic cancer)
Healthy control (without any of the above conditions)

Exclusion criteria

Under the age of 18 years
Unable to give informed consent
Inability to travel to Pittsburgh for in-person enrollment

Treatment and study plan

Primary outcomes

The data will be used in cohort association studies. Endpoints will depend on the number of patients in the study and the number of markers that are being evaluated.

Time frame: 10 years

Study contacts

Contact information is provided by the study sponsor or research team.

Beth Dudley, MS, MPH, CGC

CONTACT

[email protected]

412-623-3105

Randall E Brand, MD

CONTACT

[email protected]

412-623-3105

Sponsors and collaborators

Lead sponsor

University of Pittsburgh

Other

Registry information

Official study title

The Pancreatic Adenocarcinoma Gene Environment Risk Study -A Prospective Cohort Study of Patients at Risk or Having Pancreatic Disease

Acronym: PAGER

Important dates

Study start: 2004
Primary completion: 2027
Study completion: 2027
First posted: Jun 3, 2009
Registry last updated: Nov 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Recruiting