Painful Knee Prosthesis. Relationship Between Endogenous Analgesia and Persistent Post Surgical Pain.

This is a prospective, observational study, aimed to establish the relationship between an inefficient endogenous pain modulation before surgery (total knee arthroplasty; TKA) and the probability to develop chronic pain after surgery (persistent post surgical pain). Endogenous analgesia efficiency will be measured during the month previous to surgery using quantitative sensory testing (QST). Persistent post surgical pain will be defined as presence of pain in movement greater than 3 points in a 0-10 numerical scale in the operated knee, 6 months after surgery.

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Key information

Conditions

Knee Osteoarthritis Arthritis Joint Diseases Musculoskeletal Diseases Osteoarthritis Osteoarthritis, Knee Rheumatic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Servicio d'Anestesia i Reanimació, Hospital del Mar

Barcelona, 08003, Spain

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Older than 18 patients
Scheduled for primary total knee arthroplasty
Disposition to visits and scheduled tests

Exclusion criteria

Previous surgery on knee to be operated
Documented peripheral neuropathy
Severe disease or condition that could potentially interfere with interpretation of tests.

Treatment and study plan

Quantitative sensory testing (QST)

Behavioral

Primary outcomes

Presence of pain in the operated knee, 6 months after surgery.

Time frame: Presence of pain greater than 3 points in a 0-10 numerical scale in the operated knee, 6 months after surgery.

Secondary outcomes

Endogenous Analgesia efficiency measured with QST (Quantitative sensory testing) techniques.

Time frame: From start of recruitment untill day 180.

Sponsors and collaborators

Lead sponsor

Parc de Salut Mar

Other

Registry information

Important dates

Study start: 2013
Primary completion: 2015
Study completion: 2015
First posted: Mar 15, 2013
Registry last updated: Mar 31, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed