Pain-related Evoked Potentials in Unilateral Peripheral Nerve Injuries

The study examines pain-related evoked potentials (PREP) in patients with peripheral nerve injuries. Since previous studies found altered latencies and amplitudes of PREP in generalized polyneuropathies, e. g. HIV-polyneuropathy and fibromyalgia, this study investigates if these alterations are detectable in unilateral peripheral nerve injuries as well.

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Key information

Conditions

Peripheral Nerve Injuries Nervous System Diseases Neuromuscular Diseases Peripheral Nervous System Diseases Trauma, Nervous System Wounds and Injuries

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Peripheral Nerve Injury

Exclusion criteria

Polyneuropathy
Contralateral peripheral nerve injury
Severe psychiatric disorders
Disorders affecting central nervous system

Treatment and study plan

Pain-related evoked potentials (PREP)

Diagnostic Test

PREP were performed bilaterally with a concentric surface electrode at twice the individual pain threshold.

Quantitative sensory testing (QST)

Diagnostic Test

QST was performed bilaterally following the protocol of the German Network on Neuropathic Pain.

Nerve conduction studies (NCS)

Diagnostic Test

NCS were performed with patients only.

Primary outcomes

N1-latency

Time frame: 1 day

N1-latency of pain-related evoked potentials in ms

Secondary outcomes

N1P1-amplitude

Time frame: 1 day

Amplitude of pain-related evoked potentials in µV

Sponsors and collaborators

Lead sponsor

Ruhr University of Bochum

Other

Registry information

Official study title

Evaluation of Pain-related Evoked Potentials (PREP) for the Objectivization of Neuropathic Pain

Important dates

Study start: 2015
Primary completion: 2016
Study completion: 2016
First posted: Mar 17, 2017
Registry last updated: Mar 21, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed