Pain Processing in Inflammatory and Non-Inflammatory Chronic Pain Syndromes

Fibromyalgia (FM) is a chronic musculoskeletal pain disorder that afflicts up to 4% of the general population. The evaluation of pain mechanisms in FM has shown predominant central abnormalities and therefore has been designated as nociplastic pain syndrome. Rheumatoid arthritis (RA) is characterized by polyarthritis and pain from inflamed tissues, consistent with nociceptive pain. FM and RA patients may utilize overlapping pain mechanisms resulting in nociceptive and nociplastic pain.

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Key information

Conditions

Fibromyalgia Arthritis Arthritis, Rheumatoid Autoimmune Diseases Connective Tissue Diseases Immune System Diseases Joint Diseases Muscular Diseases Musculoskeletal Diseases Nervous System Diseases Neuromuscular Diseases Rheumatic Diseases Rheumatoid Arthritis Skin and Connective Tissue Diseases

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Florida

Gainesville, Florida, 32610, United States

Location status: Recruiting

Location contact

Melyssa Godfrey

CONTACT

[email protected]

352-265-8901

Roland Staud, MD

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Ages 18-70
Fulfills the 1990 and 2011 American College of Rheumatology Criteria for FM
Fulfills the 2010 ACR-EULAR classification criteria for RA
Healthy volunteers: No significant pain/fatigue/depression/anxiety.

Exclusion criteria

Diabetes
Cancer
Advanced liver, kidney or cardiovascular disease
Neuropathic pain

Treatment and study plan

Primary outcomes

Pressure Pain Thresholds

Time frame: One hour

Using an algometer pressure pain thresholds will be obtained several times at the upper and lower extremities

Study contacts

Contact information is provided by the study sponsor or research team.

Melyssa M Godfrey, BS

CONTACT

[email protected]

352-265-8901

Roland Staud, M.D.

CONTACT

[email protected]

352-294-8200

Sponsors and collaborators

Lead sponsor

University of Florida

Other

Registry information

Important dates

Study start: 2022
Primary completion: 2027
Study completion: 2027
First posted: Mar 14, 2022
Registry last updated: Apr 28, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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