Pain Processing and Pain Reporting in Patients With Alzheimer's Disease

The study investigates pain processing and pain reporting in patients with Alzheimers disease compared to healthy participants.

Employing a within-subject design, the study includes patients with Alzheimers disease and healthy participants that are exposed to thermal stimuli. During the test session the facial expressions of the participant are video recorded.

By repeating this on separate test days, the involvement of pain relief and pain increase is investigated.

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Key information

Conditions

Pain Alzheimer Disease Brain Diseases Central Nervous System Diseases Dementia Mental Disorders Nervous System Diseases Neurocognitive Disorders Neurodegenerative Diseases Neurologic Manifestations Pathological Conditions, Signs and Symptoms Signs and Symptoms Tauopathies

Age range

50 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Psychology and Behavioural Sciences

Aarhus, Central Jutland, 8000, Denmark

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Mild to moderate patients with Alzheimers disease (group 1)
Healthy participants ( group 2)

Exclusion criteria

Chronic pain conditions
Other medical, psychiatric or neurological disorders
Use of pain-reliving medication 24 hours prior to testing

Treatment and study plan

thermal stimulation

Behavioral

Thermal stimulation

Primary outcomes

Numerical rating scale (NRS)

Time frame: Participants will be tested on three different days. The numerical rating scale will be applied after each thermal stimulus for each test session.

Acute pain assessed on numerical rating scale from 0 (no pain experience) to 10 (worst pain), examining pain intensity. The participant will provide a number on the scale which reflects their pain intensity.

Secondary outcomes

Pain Assessment in persons with Impaired Cognition (PAIC)

Time frame: Participants will be video recorded on each of the three test days during testing.

Video recordings will be analyzed with the PAIC scale from 0 (not at all) to 3 (great degree).

Sponsors and collaborators

Lead sponsor

University of Aarhus

Other

Registry information

Important dates

Study start: 2019
Primary completion: 2021
Study completion: 2021
First posted: Oct 17, 2018
Registry last updated: Mar 31, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed