NCT Number: NCT06526572
The aim of the proposed study is to investigate and comprehensively understand pain perception in patients diagnosed with symptomatic acute pulpitis who are resistant to inferior alveolar nerve block (IANB).
The study aims to achieve this by utilizing a dual approach that combines subjective self-reporting of pain intensity using the Numeric Rating Scale (NRS) with objective neurophysiological assessment through brain wave analysis using electroencephalography (EEG).
By integrating these two methods, the study seeks to explore potential correlations between self-reported pain scores and neural responses recorded through EEG, providing insights into the pain experience of this specific patient population.
Ultimately, the goal of the study is to enhance the understanding of pain perception mechanisms in individuals with symptomatic acute pulpitis resistant to IANB and potentially guide the development of more effective and personalized pain management strategies for these patients.
Interested in participating?
Request Info18 year–50 year
All sexes
Observational
Cleveland, Ohio, 44128, United States
Location status: Recruiting
Abdelrahman Zaghloul, resident
SUB_INVESTIGATOR
Ahmed A Hashem, Profesor
CONTACT
Ahmed Basyoni, resident
SUB_INVESTIGATOR
Ahmed Hashem, Prof.
PRINCIPAL_INVESTIGATOR
Waleed Elmallah, PhD
CONTACT
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Adults aged [18-50 years]. Clinically diagnosed with symptomatic acute pulpitis based on dental examination and radiographic findings.
Demonstrates resistance to inferior alveolar nerve block (IANB). Willing and able to provide informed consent to participate in the study. Able to communicate effectively in the language used for study procedures.
Exclusion criteria
Individuals with known neurological or psychiatric disorders affecting pain perception.
Pregnant individuals or those breastfeeding at the time of the study. History of severe allergies or adverse reactions to local anesthetics or EEG gel.
Presence of significant medical conditions that may contraindicate dental procedures or EEG recordings.
Individuals taking medications that could significantly affect pain perception (e.g., strong analgesics, sedatives).
Any contraindications for dental procedures or EEG recordings as determined by the study's dental and medical professionals.
Inability to understand and follow study instructions.
Asessment of pain with objective neurophysiological assessment through brain wave analysis using electroencephalography (EEG).
Asessment of pain with the subjective numercal rate scale method (NRS
Time frame: 3 months
Changes in alpha brain waves in patients with acute pulpitis and resistant to alveolar nerve block injection
Time frame: 3 months
Measuring pain perception using NRS (Scale 0-10 where 0 is no pain and 10 is the most unbearable pain) in patients with acute pulpitis and resistant to alveolar nerve block injection.
Contact information is provided by the study sponsor or research team.
Abdelrahman Zaghloul
CONTACT
Ahmed I Basyoni
CONTACT
Cleveland Dental Institute
Other
Measuring Pain Perception in Patients With Symptomatic Acute Pulpitis and Resistant to Inferior Alveolar Nerve Block Using NRS and Brain Waves
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View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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