Skip to main content
OpenTrials
Completed

NCT Number: NCT06086483

Pain Management After Adductor Canal Block for Total Knee Arthroplasty

This randomized, double-blinded, placebo-controlled trial sought to evaluate the efficacy of the iPACK block with Adductor Canal Block on postoperative pain, functional recovery and NLR and PLR levels.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Knee Osteoarthritis Agnosia Arthritis Joint Diseases Knee Arthritis Knee Arthropathy Knee Pain Chronic Musculoskeletal Diseases Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Osteoarthritis Osteoarthritis, Knee Pathological Conditions, Signs and Symptoms Perceptual Disorders Rheumatic Diseases Signs and Symptoms

Age range

18 year–100 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Poznan University of Medical Sciences

Poznan, Poznań, 61-701, Poland

About this study

The Interspace between the popliteal artery and capsule of the posterior knee, or iPACK block, together with the Adductor Canal block (ACB), has been described and shows promise in providing analgesia to the knee joint. However, the effect of these two blocks on postoperative pain levels, functional recovery, and stress response is uncertain. This study compares a preoperative iPACK and ACB block to Sham blocks before total knee arthroplasty under spinal anesthesia.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients > 18 years old undergoing unilateral total knee arthroplasty

Exclusion criteria

  • refusal to participate
  • < 18 yo
  • Chronic opioid use
  • localized infection

Treatment and study plan

Ropivacaine 0.2% Injectable Solution

Drug

20 mL 0.5% ropivacaine was injected into the PENG block

20 mL 0.5% ropivacaine was injected into the Adductor Canal block

Other names: Ropimol

0.9%sodium chloride

Drug

20 mL 0.9% sodium chloride was injected into the PENG block

20 mL 0.5% sodium chloride was injected into the Adductor Canal block

Other names: normal saline

Primary outcomes

  1. postoperative Numeric Pain Rating Scale

    Time frame: 24 hours after surgery

    Numeric Pain Rating Scale. The 11-point numeric scale ranges from '0' representing one pain extreme (e.g. "no pain") to '10' representing the other pain extreme (e.g. "pain as bad as you can imagine" or "worst pain imaginable")

  2. postoperative Numeric Pain Rating Scale et rest

    Time frame: 48 hours after surgery

    Numeric Pain Rating Scale. The 11-point numeric scale ranges from '0' representing one pain extreme (e.g. "no pain") to '10' representing the other pain extreme (e.g. "pain as bad as you can imagine" or "worst pain imaginable")

  3. postoperative Numeric Pain Rating Scale et rest

    Time frame: 72 hours after surgery

    Numeric Pain Rating Scale. The 11-point numeric scale ranges from '0' representing one pain extreme (e.g. "no pain") to '10' representing the other pain extreme (e.g. "pain as bad as you can imagine" or "worst pain imaginable")

  4. postoperative Numeric Pain Rating Scale et rest

    Time frame: 96 hours after surgery

    Numeric Pain Rating Scale. The 11-point numeric scale ranges from '0' representing one pain extreme (e.g. "no pain") to '10' representing the other pain extreme (e.g. "pain as bad as you can imagine" or "worst pain imaginable")

  5. postoperative Numeric Pain Rating Scale during active flexion

    Time frame: 48 hours after surgery

    Numeric Pain Rating Scale. The 11-point numeric scale ranges from '0' representing one pain extreme (e.g. "no pain") to '10' representing the other pain extreme (e.g. "pain as bad as you can imagine" or "worst pain imaginable")

  6. postoperative Numeric Pain Rating Scale during active flexion

    Time frame: 72 hours after surgery

    Numeric Pain Rating Scale. The 11-point numeric scale ranges from '0' representing one pain extreme (e.g. "no pain") to '10' representing the other pain extreme (e.g. "pain as bad as you can imagine" or "worst pain imaginable")

  7. postoperative Numeric Pain Rating Scale during active flexion

    Time frame: 96 hours after surgery

    Numeric Pain Rating Scale. The 11-point numeric scale ranges from '0' representing one pain extreme (e.g. "no pain") to '10' representing the other pain extreme (e.g. "pain as bad as you can imagine" or "worst pain imaginable")

Secondary outcomes

  1. Postoperative opioid consumption

    Time frame: 96 hours after surgery

    milligrams of intravenous morphine equivalents

  2. Neutrophil-to-lymphocyte ratio

    Time frame: 12 hours after surgery

    Neutrophil-to-lymphocyte ratio

  3. Neutrophil-to-lymphocyte ratio

    Time frame: 24 hours after surgery

    Neutrophil-to-lymphocyte ratio

  4. Platelet-to-lymphocyte ratio

    Time frame: 12 hours after surgery

    Platelet-to-lymphocyte ratio

  5. Platelet-to-lymphocyte ratio

    Time frame: 24 hours after surgery

    Platelet-to-lymphocyte ratio

  6. Time to first opioid administration

    Time frame: 96 hours postoperatively

    Hours to first administration of an intravenous opioid drug

Sponsors and collaborators

Lead sponsor

Poznan University of Medical Sciences

Other

Registry information

Official study title

Pain Management and Functional Recovery After Adductor Canal Block Combined With iPACK Block for Total Knee Arthroplasty. A Prospective, Randomized, Double-blinded Clinical Trial.

Important dates

Study start
2020
Primary completion
2022
Study completion
2023
First posted
Oct 17, 2023
Registry last updated
Oct 17, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.