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OpenTrials
Completed

NCT Number: NCT07071012

Pain Control After Open Radical Nephrectomy: Thoracic Paravertebral Block Versus External Oblique Intercostal Block

This study aims to compare the effects of external oblique intercostal block versus paravertebral block on postoperative pain and complications in patients undergoing open nephrectomy.

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Key information

Conditions

Nephrectomy External Oblique Intercostal Block Neurologic Manifestations Pain Pain Scores Pain, Postoperative Paravertebral Block Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hacettepe University Faculty of Medicine Hospital

Ankara, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged 18 to 90 years
  • Scheduled for elective open radical nephrectomy for renal cell carcinoma
  • ASA classification I-III
  • Mini-Mental State Examination score ≥24
  • Provided written informed consent

Exclusion criteria

  • Neuropathy
  • Hepatic failure
  • Coagulopathy
  • Local anesthetic allergy
  • Mini-Mental State Examination score <24
  • Refusal to participate

Treatment and study plan

Bupivacaine

Drug

Used for regional anesthesia during nephrectomy procedure (e.g., paravertebral or external oblique intercostal block)

Morphine

Drug

Used for postoperative pain control via PCA device

Paracetamol

Drug

Used as part of postoperative multimodal analgesia

Diclofenac

Drug

Used as part of postoperative multimodal analgesia

Primary outcomes

  1. Postoperative Pain Score

    Time frame: Up to 24 hours after surgery

    Pain intensity measured using Visual Analog Scale at rest. (Visual Analog Scale ranging from 0 = no pain to 10 = worst pain imaginable; higher scores indicate worse pain).

Sponsors and collaborators

Lead sponsor

Hacettepe University

Other

Registry information

Official study title

Ultrasound-Guided Thoracic Paravertebral Block Versus External Oblique Intercostal Block for Postoperative Analgesia After Open Radical Nephrectomy: A Randomised Controlled Trial

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jul 17, 2025
Registry last updated
Mar 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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