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OpenTrials
Completed

NCT Number: NCT05993494

Pain, Central Sensitization, Kinesiophobia and Stress Level in Individuals With Temporomandibular Dysfunction

Temporomandibular dysfunction (TMD) is a musculoskeletal and neuromuscular system-related condition that affects the masticatory muscles, temporomandibular joint, and other related structures. Recent research has focused specifically on pain catastrophe, kinesiophobia, and central sensitization in individuals with TMD. Therefore, the aim of this study is to examine the relationship between pain, central sensitization, kinesiophobia and stress level in individuals with temporomandibular dysfunction.

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Key information

About this study

Temporomandibular dysfunction (TMD) is a musculoskeletal and neuromuscular system-related condition that affects the masticatory muscles, temporomandibular joint, and other related structures. Psychological factors are stated as comorbid in individuals with TMD. Individuals with TMD-related pain show higher levels of stress, anxiety, depression, somatic awareness, pain catastrophizing, and kinesiophobia compared to controls. Therefore, recent research has focused on pain catastrophe, kinesiophobia, and central sensitization, especially in individuals with TMD. Therefore, the aim of this study is to examine the relationship between pain, central sensitization, kinesiophobia and stress level in individuals with temporomandibular dysfunction. Ninety patients aged 18-65 years, who have TME-related complaints for at least 3 months, and diagnosed with TMD as a result of clinical and radiological evaluation by a dentist will be included in the study.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Between the ages of 18-65,
  • Having complaints related to TMJ for at least 3 months,
  • Patients diagnosed with TMD as a result of clinical and radiological evaluation by the dentist

Exclusion criteria

  • Cognitive problems,
  • Any systemic joint or muscle disease (e.g. fibromyalgia, rheumatoid arthritis),
  • Serious systemic diseases,
  • Any neurological disorder (e.g. trigeminal neuralgia),
  • Pregnancy, breastfeeding status,
  • Previous treatment for TMJ or orofacial muscle pain

Treatment and study plan

Primary outcomes

  1. Numeric Pain Scale

    Time frame: through study completion, an average of 1 year

    Pain Assessment

  2. Tampa Scale for Kinesiophobia

    Time frame: through study completion, an average of 1 year

    Kinesiophobia Assessment for temporomandibular joint dysfunction

  3. Perceived Stress Scale

    Time frame: through study completion, an average of 1 year

    Stress Assessment

  4. Central sensitization scale

    Time frame: through study completion, an average of 1 year

    Central sensitization Assessment

Sponsors and collaborators

Lead sponsor

Karadeniz Technical University

Other

Registry information

Official study title

Investigation of the Relationship Between Pain, Central Sensitization, Kinesiophobia and Stress Level in Individuals With Temporomandibular Dysfunction

Important dates

Study start
2023
Primary completion
2025
Study completion
2025
First posted
Aug 15, 2023
Registry last updated
Jul 17, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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