P53 in Differentiated Thyroid Cancer

In clinical practise patients with negative radioiodine scan with positive tyhroglobulin is considered as radioiodine resistant or in another words in the process of dedifferentiation. The aim of the present study was to search a simple blood test that could lead to early identification of patients with dedifferentiation. In this respect, we investigate whether the serum level of anti-p53 antibody has the diagnostic value in the follow-up of patients with high levels of thyroglobulin (tg) and negative I-131 scan.

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Key information

Conditions

Thyroid Neoplasms Endocrine Gland Neoplasms Endocrine System Diseases Head and Neck Neoplasms Neoplasms Neoplasms by Site Thyroid Diseases

Age range

16 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Cumhuriyet University, School of Medicine, Dept. of Nuclear Medicine

Sivas, 58140, Turkey (Türkiye)

About this study

In the present study enrolled were 171 patients with mean age of 47.7±13.5 yrs (range; 16-80yrs) and 28 healthy subjects with an age range of 18-52 yrs (mean: 36.0±9.8 yrs). 134 (78.4%) patients were female and 37 (21.6%) patients were male.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients who were diagnosed with DTC
Treated with total and/or near-total thyroidectomy
Referred for I-131 ablation therapy or low dose I-131 whole body scan (WBS)
Between December 2010 and January 2013.

Exclusion criteria

Dose 131-I given in another hospital
Radioiodine treatment more than one year after thyroidectomy.

Treatment and study plan

Primary outcomes

There was not any risk for patients.

Time frame: with in the first 8-10 months after surgery

Sponsors and collaborators

Lead sponsor

Cumhuriyet University

Other

Registry information

Official study title

P53 Antibody; Is it an Indicator of Dedifferentiated Thyroid Cancer?

Important dates

Study start: 2010
Primary completion: 2013
Study completion: 2013
First posted: Oct 1, 2013
Registry last updated: Oct 1, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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