Rambam Medical Center
Haifa, Israel
Completed
NCT Number: NCT01267357
P16 Staining as Prognostic Biomarker in Serous Papillary Endometrial Cancer
P16 is a tumor suppressor protein implicated in serous papillary endometrial carcinoma. Evidence from previous trials indicates that it may be used as a diagnostic biomarker distinguishing this disease from endometrioid endometrial cancer. Additional evidence points to its prognostic value.
The current study will evaluate p16 both as a diagnostic tool for serous papillary endometrial cancer and as a prognostic biomarker.
following anonymization, histology blocks will be microtomed and stained for P16 and P53 proteins.
Blocks from endometrioid endometrial cancer will be used as a control group.
Completed
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Notify MeKey information
Conditions
Age range
18 year and older
Sex eligibility
Female
Study type
Observational
Primary location
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- diagnosis of endometrial cancer
- histology block exists in hospital's library
Exclusion criteria
- none
Treatment and study plan
No intervention
OtherPrimary outcomes
-
Overall survival
Time frame: last followup (2-10 years)
Secondary outcomes
-
progression free survival
Time frame: Current follow up (2-10 years)
-
correlation of P16 stain with histological diagnosis
Time frame: at last follow up (2-10 years)
Sponsors and collaborators
Lead sponsor
Rambam Health Care Campus
Other
Registry information
Official study title
Expression of the P16 Protein in Serous Papillary Endometrial Cancer, and Its Clinical and Prognostic Significance
Important dates
- Study start
- 2010
- Primary completion
- 2010
- First posted
- Dec 28, 2010
- Registry last updated
- Dec 28, 2010
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.