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OpenTrials
Completed

NCT Number: NCT00946634

Ozone Therapy in Endodontic Practice, in Vivo Study

The ozone therapy has been coming up as a new therapeutic modality. Medicine has been practicing since XIX century and counted great results. It is indicated for the treatment of 260 different pathologies. The researches in Dentistry has showed promising results, indicating a wide spread action in whole dental specialties. The great oxidative power of ozone provides a great antimicrobial effect and it increases the adenosine triphosphate (ATP) synthesis that can be considered as a general improvement of the cell metabolism, which can potentize the repair process. Thus, these facts justify the present study which will assess the increase of speed of apical periodontite repair.

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Key information

Conditions

Primary Apical Periodontite

Age range

13 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

Fundação para o Desenvolvimento Científico e Tecnológico da Odontologia of University of Sao Paulo

São Paulo, 05508-000, Brazil

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy patients
  • Radiographic evidence of apical periodontite
  • No previous root canal treatment

Exclusion criteria

  • Unhealthy patients
  • Regular response to sensibility test
  • Previous root canal treatment

Treatment and study plan

Ozone

Drug

Regular endodontic protocol preconized by University of Sao Paulo. Root canal irrigation with 1% Sodium Hypochlorite associated to Endo PTC (10mL), final irrigation with EDTA-T 17% remaining for 3 minutes. After a last foaming with ozone gas (Philozon, Santa Catarina, Brazil) at 40mg/L concentration.

Other names: Group 2

Control (no last irrigation)

Drug

Regular endodontic protocol preconized by University of Sao Paulo. Root canal irrigation with 1% Sodium Hypochlorite associated to Endo PTC (10mL), final irrigation with EDTA-T 17% remaining for 3 minutes.

Other names: Group 1

Aqueous Ozone

Drug

Regular endodontic protocol preconized by University of Sao Paulo. Root canal irrigation with 1% Sodium Hypochlorite associated to Endo PTC (10mL), final irrigation with EDTA-T 17% remaining for 3 minutes. A last irrigation with 10mL of ozonated water at 40mg/mL concentration

Other names: Group 3

Primary outcomes

  1. Acceleration in repair by healing of apical periodontite

    Time frame: 3 months

Sponsors and collaborators

Lead sponsor

University of Sao Paulo

Other

Collaborators

  • Fundação de Amparo à Pesquisa do Estado de São Paulo

Registry information

Official study title

Phase 4 - Ozone Therapy in Endodontic Practice, in Vivo Study

Important dates

Study start
2009
Primary completion
2009
Study completion
2011
First posted
Jul 27, 2009
Registry last updated
Oct 4, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.