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Active, Not Recruiting

NCT Number: NCT07549672

Ozone Oil-based Gel and CHX Gel After Lower Third Molar Removal

Overall, 100 patients of both genders were included in the study, with indication of surgical extraction of lower third molar, positioned similarly after being clinically and radiographically checked by X-ray and orthopantomography. Each patient was subjected to both groups in separate sessions: treated with ozone gas and with CHX gel 1%. Data on pain intensity, number of taken analgesics- painkillers, and dry socket were recorded for 48 h and at Day 7

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Conditions

Pain Dry Socket Mouth Diseases Neurologic Manifestations Pathological Conditions, Signs and Symptoms Signs and Symptoms Stomatognathic Diseases

Age range

21 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Early Phase 1

Primary location

ASSOCIATE PROFESSOR cairo university

Cairo, Cairo Governorate, 12515, Egypt

About this study

Overall, 100 patients of both genders were included in the study, with indication of surgical extraction of lower third molar, positioned similarly after being clinically and radiographically checked by X-ray and orthopantomography. Each patient was subjected to both groups in separate sessions: treated with ozone gas and with CHX gel 1%. Data on pain intensity, number of taken analgesics- painkillers, and dry socket were recorded for 48 h and at Day 7

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with third impacted bilateral molars, symmetrically in the same position, position evaluated by radiography.
  • Patients in whom operative extraction of third molars is indicated with the creation of a mucoperiosteal flap.
  • Patients regardless of gender.

Exclusion criteria

  • Voluntary exclusion of the patient.
  • lack of cooperation in any of the work phase

Treatment and study plan

Ozone Oil-based Gel

Drug

Overall, 30 patients of both genders were included in the study, with indication of surgical extraction of lower third molar, positioned similarly after being clinically and radiographically checked by X-ray and orthopantomography. Each patient was subjected to both groups in separate sessions: treated with ozone gas and with CHX gel 1%. Data on pain intensity, number of taken analgesics- painkillers, and dry socket were recorded for 48 h and at Day 7

Other names: CHX Gel

Primary outcomes

  1. pain severity

    Time frame: 7 days

    pain scale ( VAS ; visual analogue scale) (1-10)

Secondary outcomes

  1. dry socket incidence

    Time frame: 15 daays

    bare socket (binary yes/no)

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Comparing Ozone Oil-based Gel and CHX Gel Applications to Reduce Pain and Incidence of Dry Socket After Lower Third Molar Extraction, a Randomized Clinical Study

Important dates

Study start
2023
Primary completion
2026
Study completion
2026
First posted
Apr 24, 2026
Registry last updated
Apr 28, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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