Skip to main content
OpenTrials
Completed

NCT Number: NCT04413786

Oxytocin's Effects on Face Attentional Processing

To investigate whether intranasal oxytocin (24IU) treatment has a regulatory effect on attentional processing of emotional faces.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Healthy

Age range

18 year–30 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

School of life science and technology, University of Electronic Science and Technology of China

Chengdu, Sichuan, 611731, China

About this study

In a placebo-controlled double-blind between-subject design experiment, investigators plan to investigate the effect of oxytocin treatment on attentional processing of emotional faces. Subjects complete questionnaires in Chinese versions before treatment administration, including the Beck Depression Inventory, Autism Spectrum Quotient , Trait Anxiety Inventory, Toronto Alexithymia Scale, Multidimentional Assessment of Interoceptive Awareness. This experiment consists of two tasks including Emotional Face Cue-target Task and Visual Search Task. In the first task, subjects need to make a response to judge the position of target after a cue-target is presented. In the second task, subjects are asked to search the target "U" or inverted "U" placed on the nose of emotional/neutral faces and make an choices based on their oorientation. During these phases, subjects' response accuracy, response time and electrophysiological activity (ERP) are recorded.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy subjects without past or current psychiatric or neurological disorders.

Exclusion criteria

  • history of head injury
  • medical or psychiatric illness

Treatment and study plan

oxytocin treatment

Drug

intranasal administration of oxytocin (24IU)

placebo treatment

Drug

intranasal administration of placebo (24IU)

Primary outcomes

  1. Response time in reponse to different emotional face targets.

    Time frame: 1 hour

    Response time in discriminating which side (left or right) the emotional face target appear.

  2. N2pc

    Time frame: 1 hour

    N2pc is an enhanced negative event-related potential typically elicited at posterior electrodes (e.g., PO7 and PO8) contralateral to the target presented among distractors between 180 and 300 ms after the onset of stimuli.

    display.

Secondary outcomes

  1. Response accuracy in response to different emotional face targets.

    Time frame: 1 hour

    Response accuracy is caculated by the precentage of correct responses among the total responses in discriminating the position (left or right side) of different face conditions.

Sponsors and collaborators

Lead sponsor

University of Electronic Science and Technology of China

Other

Registry information

Official study title

The Modulatory Effect of Oxytocin on Attentional Processing of Emotional Faces

Important dates

Study start
2019
Primary completion
2021
Study completion
2021
First posted
Jun 4, 2020
Registry last updated
Feb 9, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.