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Completed

NCT Number: NCT03486925

Oxytocin Effect on Attention Inhibition

Effects of intranasal oxytocin (24IU) on cognitive control of attention

Completed

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Key information

Conditions

Healthy

Age range

18 year–30 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

School of Life Science and Technology, University of Electronic Science and Technology of China

Chengdu, Sichuan, 611731, China

About this study

The cognitive control of attention towards neutral and emotional stimuli represents a key functional domain and disruptions in this domain have been associated with a range of psychiatric disorders. Saccadic eye movement tasks have been used to assess individual differences in the cognitive control of attention and alterations in psychiatric disorders. Recent evidence suggests that the hypothalamic neuropeptide Oxytocin (OXT) may modulate attention allocation and regulation. To this end the present randomized between-subject placebo-controlled experiment examined whether intranasal OXT modulates behavior in an eye-tracking saccade / anti-saccade paradigm in healthy male subjects. The paradigm used non-social (neutral shape) as well as social (happy, sad, angry, fear, and neutral faces) stimuli to explore emotion-specific effects of OXT.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male, healthy participants
  • Non smokers

Exclusion criteria

  • Previous or current medical, psychiatric, neurological disorder
  • Regular medication
  • Use of any psychoactive substances in the 24 hours before experiment
  • Contra-indications for oxytocin
  • Contra-indications for eye-tracking data acquisition

Treatment and study plan

oxytocin treatment

Drug

intranasal administration of oxytocin (24IU)

placebo treatment

Drug

intranasal administration of placebo

Primary outcomes

  1. emotion-specific saccade latencies

    Time frame: 45 minutes - 100 minutes after treatment

    comparison between emotion-specific saccade latencies between the treatment groups (in milliseconds)

  2. emotion-specific error rates

    Time frame: 45 minutes - 100 minutes after treatment

    comparison between the emotion-specific ratio of unsuccessful anti-saccades between the treatment groups.

Sponsors and collaborators

Lead sponsor

University of Electronic Science and Technology of China

Other

Registry information

Official study title

An Eye-tracking Study to Investigate Oxytocin Effect on Attention Inhibition

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Apr 3, 2018
Registry last updated
Mar 4, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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