Skip to main content
OpenTrials
Not Yet Recruiting

NCT Number: NCT07487324

Oxygenation in Posterior Stabilization Surgery

This study aims to evaluate the effects of prone positioning on oxygenation, ventilation, and hemodynamic parameters in patients undergoing posterior stabilization surgery under general anesthesia. By comparing routine anesthesia and monitoring data obtained in the supine and prone positions, the study seeks to determine how positional changes influence respiratory mechanics and perioperative physiological stability.

Not Yet Recruiting

Trial opening soon.

Get Notified

Key information

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Sakarya Universt

Sakarya, Karabük Province, 78000, Turkey (Türkiye)

About this study

The prone position is frequently used during posterior stabilization surgery, yet it is associated with important physiological changes that may affect both respiratory and hemodynamic function under general anesthesia. Previous studies have shown that prone positioning may improve ventilation-perfusion matching, increase functional residual capacity, and enhance oxygenation. At the same time, position-related alterations in thoracic mechanics, airway pressures, venous return, and cardiovascular parameters may influence intraoperative management.

This study is designed to comprehensively assess the physiological effects of prone positioning in anesthetized patients undergoing posterior stabilization surgery. Routine anesthesia and monitoring data collected during mechanical ventilation will be analyzed and compared between the supine and prone positions. Particular focus will be placed on oxygenation, ventilation variables, respiratory mechanics, and hemodynamic parameters in order to evaluate the impact of positional change.

In addition, the study aims to identify which clinical and monitoring findings should be prioritized during anesthetic management of patients in the prone position. By clarifying the relationship between positioning and perioperative physiological responses, the study seeks to contribute to safer anesthetic practice and to support the maintenance of adequate oxygenation and hemodynamic stability throughout surgery.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients aged 18 to 75 years Patients classified as ASA physical status I, II, or III according to the American Society of Anesthesiologists Patients undergoing posterior stabilization surgery Patients who voluntarily agreed to participate in the study Patients with a body mass index (BMI) <35 kg/m² Patients followed with a standard mechanical ventilation procedure

Exclusion criteria

  • - ASA 4 olarak değerlendirilenler
  • Anestezik ajan alerjisi olanlar
  • Kanama diatezi bozukluğu olanlar
  • Cerrahi süresi 3 saatin üstünde olanlar
  • Bilinen ileri akciğer hastalığı olanlar (intertisyel akciğer hastalığı, ileri düzey KOAH, ileri düzey astım vb)
  • VKI≥35 olanlar
  • Obstrüktif uyku apne sendromu tanısı olanlar
  • Toraks deformitesi olanlar
  • Ciddi kalp yetmezliği öyküsü olanlar (EF<30)
  • Şiddetli anemi öyküsü olanlar (Hg<8 mg/dl)
  • Cerrahi operasyon sırasında kan transfüzyonu ihtiyacı olan hastalar

Treatment and study plan

blood gase

Other

Arterial blood gas samples will be obtained from patients, and alveolar oxygenation ratios will be compared between the supine and prone positions.

Primary outcomes

  1. Change in alveolar oxygenation between supine and prone positions

    Time frame: within 20 minutes after anesthesia induction

    The primary outcome of this study is to evaluate the difference in alveolar oxygenation between the supine and prone positions in patients undergoing posterior stabilization surgery. Arterial blood gas samples obtained during surgery will be used to compare oxygenation parameters measured in both positions and to assess the effect of positional change on oxygenation.

Secondary outcomes

  1. Change in optic nerve sheath diameter between supine and prone positions

    Time frame: intraoperatively

    The secondary outcome is the comparison of optic nerve sheath diameter measurements obtained in the supine position and after positioning the patient prone during posterior stabilization surgery. This assessment is intended to evaluate the effect of positional change on optic nerve sheath diameter.

Study contacts

Contact information is provided by the study sponsor or research team.

HAVVA KOCAYİĞİT, Associate Professor

CONTACT

[email protected]

905425950020

Sponsors and collaborators

Lead sponsor

Sakarya University

Other

Registry information

Official study title

Factors Determining Oxygenation in Posterior Stabilization Surgery: The Role of Positioning and Mechanical Ventilation Parameters

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Mar 23, 2026
Registry last updated
Mar 23, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.