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Completed

NCT Number: NCT03386318

Oxycodone Concentration in the Blood After Oral Premedication

Oxycodone is an opioid frequently given orally as a premedication prior to any kind of surgery. The initial studies are performed on healthy testpersons and is not given in surgery. The investigators want to explore serum concentration over time (5h) and relate this to Visual Analoge Scale (VAS) postoperatively but also to given mg/kg

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Key information

Conditions

Oxycontin

Age range

30 year–60 year

Sex eligibility

Female

Study type

Observational

Primary location

Sahlgrenska UH

Mölndal, Västra Götaland County, 43180, Sweden

About this study

Oxycodone is an opioid frequently given orally as a premedication prior to any kind of surgery. The initial studies are performed on healthy test-persons and is not given in surgery. The investigators want to explore serum concentration over time (5h) and relate this to Visual Analoge Scale (VAS) postoperatively but also to given mg/kg 20 female patients between 30 and 60 years will be included after informed consent. They will have day-surgery. The patients will receive 5 mg oxycodone if weighing less than 60 kg and 10 mg if weighing over 60 kg. Serum samples will be taken 1, 2,3,4, and 5 hours after medication intake and serum concentrations will be analyzed

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Females <100kg, non-opioid tolerant, day surgery and informed consent

Exclusion criteria

  • In complying to inclusion criterias

Treatment and study plan

Oxycodone

Drug

Serum concentration per hour from 1 to 5 h

Primary outcomes

  1. Oxycodone concentration in the blood after oral premedication

    Time frame: 2 days

    Concentration study

  2. Oxycodone concentrations and pain after oral premedication

    Time frame: 7 day

    Visual analoge Scale

Sponsors and collaborators

Lead sponsor

Sahlgrenska University Hospital

Other

Registry information

Important dates

Study start
2019
Primary completion
2020
Study completion
2021
First posted
Dec 29, 2017
Registry last updated
May 10, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.