Oxidative Stress Markers in COPD

Background:Striking feature of Chronic obstructive pulmonary disease (COPD) is its inability to resolve after cigarette smoke exposure has ended, which has contributed to the possibility that the disease could also be driven by other endogenous causes, such as autoimmunity or chronic infection . Many of the pathogenetic pathways involved in COPD and its development tend to be driven by oxidative stress.

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Key information

Conditions

Role of Oxidative Stress in COPD Chronic Disease Disease Attributes Lung Diseases Lung Diseases, Obstructive Pathologic Processes Pathological Conditions, Signs and Symptoms Pulmonary Disease, Chronic Obstructive Respiratory Tract Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

Minia University Hospital

Multiple Locations, Minya Governorate, 61691, Egypt

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

1-Forty subjects of COPD who are non-smokers or stopped smoking for more than 6 months Based on the Global Initiative for Chronic Obstructive Lung Disease guidelines, COPD was diagnosed.9 2- Thirty subjects of non smokers healthy control

Exclusion criteria

Patients of:

Acute exacerbation, at the time of the study, of COPD.
Any obvious abnormal lung parenchymal lesions.
Lung cancer.
Congestive heart failure.
current smokers
Drugs e.g anti-inflammatory , steroids ,analgesics, insulin , antineoplastic, antipsychotic drugs in the previous 2 weeks before the study.

Treatment and study plan

oxidative stess markers

Other

markers of oxidative stress , Superoxide Dismutase (SOD) and Malondialdehyde (MDA) by ( ELISA Kit SinoGeneClon Biotech Co.,Ltd Catalog No : SG- 10188) .

Other names: Superoxide Dismutase (SOD) and Malondialdehyde (MDA)

Primary outcomes

oxidative stress markers in non smokers COPD compared to healthy control

Time frame: 1month

markers of oxidative stress , Superoxide Dismutase (SOD) and Malondialdehyde (MDA) by ( ELISA Kit SinoGeneClon Biotech Co.,Ltd Catalog No : SG- 10188) .

Sponsors and collaborators

Lead sponsor

Minia University

Other

Registry information

Official study title

Chronic Obstructive Pulmonary Disease in Non Smokers:Role of Oxidative Stress

Important dates

Study start: 2018
Primary completion: 2019
Study completion: 2019
First posted: Feb 10, 2021
Registry last updated: Feb 10, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed