Oxidation-reduction Homeostasis in Cognitive Impairment Patients After Stroke

Cognitive impairment after ischemic stroke can affect not only the social adaptation ability, but also affect the comprehensive rehabilitation of patients. The damage of cognitive impairment after ischemic stroke is not lower than the body function defect after stroke. Many studies have shown that oxidative stress is one of the pathophysiological mechanisms of ischemic cerebrovascular disease. Many studies have reported that the oxidative-reduction of cells plays an important role in the life activities of organisms, affecting the health, aging and death of the organism. In the recent years, some scholars have suggested that post-stroke cognitive impairment may be related to oxidative-reduction homeostasis of the body, but the relevant evidence is lacking and needs to be further explored. Therefore, the purpose of this study is to explore the effect of oxidation-reduction homeostasis on cognitive impairment in patients with ischemic stroke, and provide a theoretical basis for the prevention and treatment of cognitive impairment after ischemic stroke.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Oxidative-reduction Homeostasis Post-stroke Cognitive Impairment

Age range

40 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

General Hospital of ShenYang Military Region

Shenyang, Liaoning, 10016, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

40-80 years old;
Ischemic stroke for the first time or previous stroke but with no serious sequelae (mRS is 0 -2 points);
Time from onset to treatment ≤48 hours;
Conscious awareness, and with no obvious aphasia and visual impairment;
Signed informed consent by patient self or legally authorized representatives.

Exclusion criteria

Intracranial hemorrhage or suspected subarachnoid hemorrhage;
Transient ischemic attack;
Patients with severe mental disorders or language disorders;
Patients can not cooperate with evaluators, such as mental illness or dementia;
Pregnant women or suckers;
Researchers consider patients inappropriate to participate in the registry.

Treatment and study plan

No intervention has been conducted

Other

It is an observational study, and no intervention has been conducted

Primary outcomes

Oxidative-reduction homeostasis in acute ischemic stroke patients

Time frame: 1 day

Reduced glutathione (GSH)/ Oxidized glutathione (GSSG), Superoxide dismutase (SOD), Catalase (CAT), Glutathione Peroxidase (GSH-PX) of acute ischemic stroke patients will be tested.
Cognitive function in acute ischemic stroke patients

Time frame: 1 day

Mini Mental Status Examination (MMSE) and Montreal cognitive assessment scale (MoCA) in acute ischemic stroke patients will be evaluated.

Sponsors and collaborators

Lead sponsor

Hui-Sheng Chen

Other

Registry information

Official study title

Effects of Oxidation-reduction Homeostasis on Cognitive Impairment in Patients With Ischemic Stroke

Important dates

Study start: 2018
Primary completion: 2018
Study completion: 2019
First posted: May 9, 2018
Registry last updated: Jul 31, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed