Skip to main content
OpenTrials
Completed

NCT Number: NCT02048891

Ovulation Trigger With hCG Compared to GnRH Agonist in Patients With Repeated IVF Failures

Ovulation trigger is needed in in vitro fertilization (IVF) to get mature eggs. Routinely, human chorionic gonadotropin (hCG) is used for that purpose given its similarity to the natural hormone that does this job in a natural cycle (luteinizing hormone, LH). In a natural cycle another hormone takes part in the process (follicle stimulating hormone, FSH). To induce a natural-like ovulation surge that includes LH and FSH , gonadotropin releasing hormone (GnRH) agonist can be given.

The purpose of this study is to find out which approach may work better in IVF patients who experienced 4 IVF failures.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Infertility Genital Diseases Urogenital Diseases

Age range

35 year–44 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 4

Primary location

IVF Unit, Rambam medical Center

Haifa, Israel, 31096

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • IVF patients with at least 4 consecutive failures.
  • On trigger day, no more than 10 follicles of 12 mm and up

Exclusion criteria

  • History of moderate or severe OHSS.

Treatment and study plan

GnRH agonist trigger

Drug

Other names: Oovulation trigger with Decapeptyl 0.2 mg, luteal support with 2 injections of 1,500 U hCG.

HCG trigger

Drug

Other names: Ovulation trigger with Ovitrelle 250 microgram., Luteal support with daily progesterone gel = Crinone 8%

Primary outcomes

  1. Fetal Heart Activity 1 Month After Oocyte Retrieval

    Time frame: 1 month after oocyte retrieval

    Fetal heart activity as seen by vaginal ultrsound imaging 1 month after oocyte retrieval

Secondary outcomes

  1. Patients Comfort During the Luteal Phase

    Time frame: During 2 weeks from day of oocyte retrieval

Sponsors and collaborators

Lead sponsor

Rambam Health Care Campus

Other

Registry information

Important dates

Study start
2014
Primary completion
2015
Study completion
2015
First posted
Jan 29, 2014
Registry last updated
Jun 8, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.